501373-03-1

Basic information

• Product Name: 5,8-DIFLUORO-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE
• Synonyms: 5,8-DIFLUORO-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE
• CAS NO: 501373-03-1
• Molecular Formula: C₁₀H₈F₂O
• Molecular Weight: 0
• Mol File: 501373-03-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5,8-DIFLUORO-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5,8-DIFLUORO-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE(501373-03-1)
• EPA Substance Registry System: 5,8-DIFLUORO-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE(501373-03-1)

Safety Data

• Hazardous Substances Data: 501373-03-1(Hazardous Substances Data)

Usage

General Description

5,8-DIFLUORO-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE is a chemical compound with the molecular formula C10H8F2O. It is a white to off-white solid substance that is insoluble in water but soluble in organic solvents. 5,8-DIFLUORO-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE is used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. It is also utilized in the research and development of new chemicals and materials. Additionally, 5,8-DIFLUORO-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE may have potential applications as a pesticide or agrochemical with further investigation and development. Overall, this chemical has various industrial and scientific uses due to its versatile properties and potential for further functionalization.

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Relevant articles and documents

BENZENESULFONYL-CHROMANE, THIOCHROMANE, TETRAHYDRONAPHTHALENE AND RELATED GAMMA SECRETASE INHIBITORS

This invention discloses novel gamma secretase inhibitors of the formula: R2 and R3, or R2 and R4, or R3 and R4, together with the atoms to which they are bound, can form a fused cycloalkyl

Synthesis of mono- and difluoronaphthoic acids

Aryl carboxamides are useful structural units found in several biologically active compounds. Unlike their benzoic acid counterparts, fluorinated versions of naphthoic acids are relatively unknown. In connection with a recent project, we needed viable syntheses of several mono- and difluorinated naphthoic acids. Herein we describe the synthesis of 5-, 6-, 7-, and 8-fluoro-1-naphthalenecarboxylic acids and 5,7-, 5,8-, 6,7-, and 4,5-difluoro-1-naphthalenecarboxylic acids. The 5-fluoro derivative 1 was obtained from the corresponding 5-bromo compound via electrophilic fluorination of the lithio-intermediate. The rest of the monofluoro (2, 3, and 4) and the difluoro acids (5, 6, and 7) were prepared by a new, general route which entailed the elaboration of commercial fluorinated phenylacetic acids to 2-(fluoroaryl)glutaric acids with differential ester groups; selective hydrolysis to a mono acid, intramolecular Friedel-Crafts cyclization, and aromatization furnished the target structures. An alternative process to assemble a naphthalene skeleton is also presented for the difluoro acids 5 and 6. Finally, 4,5-difluoro-1-naphthalenecarboxylic acid (8) was prepared expeditiously from 1,8-diaminonaphthalene by adapting classical reactions.