501378-89-8

Upstream product

• 22717-56-2 4-bromo-2-Hydroxybenzoic Acid Methylester 
• 16420-13-6 N,N-Dimethylthiocarbamoyl chloride 
• 65-49-6 4-Aminosalicylic acid 
• 1666-28-0 4-bromosalicylic acid 

Downstream Products

• 116209-30-4 4-bromo-2-mercaptobenzoic acid 
• 501378-90-1 4-bromo-2-dimethylcarbamoylsulfanyl-benzoic acid methyl ester 

Relevant academic research and scientific papers

THIOCHROMENE DERIVATIVES AS HIP HYDROXYLASE INHIBITORS

The present invention relates to novel compounds, methods, and compositions capable of decreasing HEF hydroxylase enzyme activity, thereby increasing the stability and/or activity of hypoxia inducible factor (HIF).

1,3-BENZOTHIAZINONE DERIVATIVES AND USE THEREOF

This invention provides a compound represented by the formula (I) :wherein R1 is a hydrogen atom, a halogen atom, hydroxy, nitro, optionally halogenated alkyl, alkoxy optionally having substituents, acyl or amino optionally having substituents;R2 is pyridyl, furyl, thienyl, pyrrolyl, quinolyl, pyrazinyl, pyrimidinyl, pyridazinyl, indolyl, tetrahydroquinolyl or thiazolyl, each of which may have substituents;n is 1 or 2; or a salt. And this invention provides a safe pharmaceutical comprising the compound of the formula (I) , which has an excellent apoptosis inhibitory effect and MIF binding effect, for preventing and/or treating heart disease, nervous degenerative disease, cerebrovascular disease, central nervous infectious disease, traumatorathy, demyelinating disease, bone and articular disease, kidney disease, liver disease, osteomyelodysplasia, AIDS, cancer, and the like.