501420-63-9

Usage

Uses

Used in Pharmaceutical Industry:
3-Bromo-4-fluorobenzeneacetonitrile is used as a key intermediate in the synthesis of pharmaceuticals for its ability to be easily modified and incorporated into complex molecular structures. Its presence in drug molecules can contribute to enhancing their therapeutic properties and improving their pharmacokinetic profiles.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Bromo-4-fluorobenzeneacetonitrile serves as a crucial building block for the development of new pesticides and other agrochemicals. Its unique structure allows for the creation of compounds with targeted pest control properties, contributing to more effective and environmentally friendly agricultural practices.
Used in Dye and Pigment Production:
3-Bromo-4-fluorobenzeneacetonitrile is utilized as an intermediate in the production of dyes and pigments due to its capacity to form stable chromophores. This results in the creation of colorants with improved colorfastness and performance in various applications, such as textiles, plastics, and printing inks.
Safety Considerations:
Given the reactivity of 3-Bromo-4-fluorobenzeneacetonitrile, it is essential to handle 3-Bromo-4-fluorobenzeneacetonitrile with care and adhere to proper safety protocols during its use in research and industrial applications. This includes the use of appropriate personal protective equipment, working in well-ventilated areas, and following guidelines for safe storage and disposal.

Upstream product

• 773837-37-9 sodium cyanide 
• 866862-23-9 3-bromo-4-fluorobenzyl metanesulfonate 
• 78239-71-1 3-bromo-4-fluorobenzyl bromide 
• 77771-03-0 3-bromo-4-fluoro-benzyl alcohol 
• 77771-02-9 3-bromo-4-fluorobenzaldehyde 
• 143-33-9 sodium cyanide 

Downstream Products

• 1159186-66-9 4-(3-bromo-4-fluorophenyl)-tetrahydro-2H-pyran-4-carbonitrile 
• 1239964-06-7 2-(3-bromo-4-fluorophenyl)-2-methylpropanenitrile 

Relevant academic research and scientific papers

Oxadiazole Amine Derivative Compounds as Histone Deacetylase 6 Inhibitor, and the Pharmaceutical Composition Comprising the same

The present invention relates to a novel compound having an activity of inhibiting histone deacetylase 6 (HDAC6), an optical isomer thereof or a pharmaceutically acceptable salt thereof, a use thereof for preparation of a drug for treatment, a pharmaceutical composition comprising the same, a treatment method using the composition, and a method for preparing the same. The novel compound, an optical isomer thereof or a pharmaceutically acceptable salt thereof according to the present invention has an activity of inhibiting histone deacetylase 6 (HDAC6), and is effective for preventing or treating HDAC6-related diseases, including infectious diseases; neoplasm; endocrine, nutritional and metabolic diseases; mental and behavior disorders; nerve disorders; eye and adnexa diseases; cardiovascular diseases; respiratory diseases; digestive organ diseases; skin and subcutaneous tissue diseases; musculoskeletal and connective tissue diseases; or congenital malformation, deformation and chromosomal abnormality.COPYRIGHT KIPO 2017

TGR5 AGONISTS

TGR5 agonists of structural formula VIII(Q), wherein X, R1, R2, and R5 are defined in the specification, pharmaceutically acceptable salts thereof, compositions thereof, and use of the compounds and compositions for treating diseases. The invention also comprises use of the compounds in and for the manufacture of medicaments, particularly for treating diseases.

TRIAZOLE AND IMIDAZOLE DERIVATIVES FOR USE AS TGR5 AGONISTS IN THE TREATMENT OF DIABETES AND OBESITY

The present invention comprises TGR5 agonists of structural formula I, wherein X, R1, R2, and R5 are defined herein, as well as N-oxides of them and pharmaceutically acceptable salts thereof. The invention further comprise

PYRAZOLE DERIVATIVES AS 5-LO INHIBITORS

The invention relates to compounds of formula (I) processes for their preparation, their use as 5-lipoxygenase inhibitors and pharmaceutical compositions containing the same.