501421-95-0

Upstream product

• 3078-09-9 benzaldehyde p-nitrophenylhydrazone 
• 17571-17-4 4-benzoyl-5-phenyl-furan-2,3-dione 

Downstream Products

• 501422-05-5 4-benzoyl-1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-3-carbonitrile 
• 501421-99-4 4-benzoyl-1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-3-carboxamide 

Relevant academic research and scientific papers

Reactions of some pyrazole-3-carboxylic acids with various N,N'-binucleophiles and investigation of their antiproliferative activities

Synthesis, characterization, and antiproliferative activity evaluation of a series of novel pyrazole bis-carboxamide derivatives (8-12) have been described. Synthesized molecules have been screened to evaluate their antiproliferative activities against HeLa (human uterus carcinoma), Vero (green monkey kidney), and C6 (Rat Brain tumor) cells as in vitro. The tests are carried out as dose-dependent assay starting from 100 μg/mL to 500 μg/mL. Generally the compounds have been shown to possess weak antiproliferative activity against all cell lines as compared with Cisplatin and 5-Fluorouracil. Only compound 8 shows moderate antiproliferative activity against Hela cancer cells.

Studies on the reactions of cyclic oxalyl compounds with hydrazines or hydrazones: Synthesis and reactions of 4-benzoyl-1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid

The 1H-pyrazole-3-carboxylic acid 2, obtained from the furan-2,3-dione 1 and N-Benzylidene-N′-(3-nitrophenyl) hydrazine, was converted via reactions of its acid chloride 3 with various alcohols or N-nucleophiles into the corresponding ester or amide derivatives 4 or 5, respectively. Nitrile 6 and anilino-pyrazole acid 7 derivatives of 2 were also obtained by dehydration of 5a in a mixture of SOCl2 with DMF and reduction of 2 with sodium polysulphide, respectively. While cyclocondensation reactions of 2 or 7 with phenyl hydrazine or hydrazine hydrate and 6 with only anhydrous hydrazine lead to derivatives of pyrazolo[3,4-d]-pyridazinone 8 and pyrazolo[3,4-d]pyridazine amine 9, respectivel. The reaction of 2 with 2-hydrazinopyridine provided hydrazono-pyrazole acid derivative 10, which was decarboxylated to give hydrazono-pyrazole derivative 11. Pyrazolo[4,3-d]oxazinone 12 and 2-quinolyl pyrazolo[3,4-d]pyridazine 13 derivatives were also prepared by cyclocondensation reactions of 2 with hydroxylamine hydrochloride and 7 with acetaldehyde, respectively.