501422-37-3Relevant academic research and scientific papers
Palladium-catalyzed cyclization of N-n-butyl, N-(o-iodobenzyl)-3-butenamides: Six- versus seven- and eight-membered ring formation
Ferraccioli, Raffaella,Carenzi, Davide,Catellani, Marta
, p. 1860 - 1864 (2007/10/03)
The regiochemistry of the palladium-catalyzed annulation of N-n-butyl, N-(o-iodobenzyl)-3-butenamides 1 can be dramatically varied by addition of water to the reaction mixture. In anhydrous DMF 1 lead to 6-membered ring formation, while in aqueous DMF 7/8
