501443-29-4

Basic information

• Product Name: 2-Cyclohexen-1-one,3-ethoxy-4,4-dimethyl-(9CI)
• Synonyms: 2-Cyclohexen-1-one,3-ethoxy-4,4-dimethyl-(9CI)
• CAS NO: 501443-29-4
• Molecular Formula: C₁₀H₁₆O₂
• Molecular Weight: 168.23284
• Product Categories: CYCLOHEXANONE
• Mol File: 501443-29-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Cyclohexen-1-one,3-ethoxy-4,4-dimethyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Cyclohexen-1-one,3-ethoxy-4,4-dimethyl-(9CI)(501443-29-4)
• EPA Substance Registry System: 2-Cyclohexen-1-one,3-ethoxy-4,4-dimethyl-(9CI)(501443-29-4)

Safety Data

• Hazardous Substances Data: 501443-29-4(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 562-46-9 4,4-dimethylcyclohexane-1,3-dione 

Downstream Products

• 1073-13-8 4,4-dimethylcyclohexenone 

Relevant articles and documents

Enantioselective Synthesis of cis-Decalin Derivatives by the Inverse-Electron-Demand Diels–Alder Reaction of 2-Pyrones

A novel strategy for the synthesis of cis-decalins by an ytterbium-catalyzed asymmetric inverse-electron-demand Diels–Alder reaction of 2-pyrones and silyl cyclohexadienol ethers is reported here. A broad range of synthetically important cis-decalin derivatives with multiple contiguous stereogenic centers and functionalities are obtained in good yields and stereoselectivities. A full set of diastereomeric substituted cis-decalin motifs are readily accessible by tuning the absolute configurations of substituted silyl cyclohexadienol ethers (R or S) as well as the ligands (R or S). The synthetic potential is showcased by the enantioselective total synthesis of 4-amorphen-11-ol, and further demonstrated by the first total synthesis of cis-crotonin.

Enzymatic resolution of racemic secondary cyclic allylic alcohols

The resolutions of five racemic cyclic alcohols: 6,6-dimethylcyclohex-2-en-1-ol (±)-5, 4,4-dimethylcyclohex-2-en-1-ol (±)-7, 5,5-dimethylcyclohex-2-en-1-ol (±)-11 and isomeric trans-(±)-13 and cis-piperitols (±)-14 are presented. They were resolved by enzymatic esterification with vinyl esters or by enzymatic hydrolysis of their racemic esters in phosphate buffer. The following lipases were used as biocatalysts: Novozyme 435 (Candida antarctica), Amano PS (Burkholderia cepacia) and lipase from Candida cylindracea. All isomers of alcohols were obtained with at least 96% ee.

Efficient formal synthesis of (±)-hyphodermin B

An efficient formal synthesis of hyphodermin B 1, a metabolite of Hyphoderma radula, has been completed in 15% overall yield. The tricyclic carbon skeleton 3 was rapidly assembled from a novel vinyl enone via a Diels-Alder reaction, followed by dehydrogen