501446-98-6Relevant academic research and scientific papers
Condensation of 2-aminomethylaniline with aldehydes and ketones for the fast one-pot synthesis of a library of 1,2,3,4-tetrahydroquinazolines under flow conditions
Mangiavacchi, Francesca,Mollari, Leonardo,Bagnoli, Luana,Marini, Francesca,Santi, Claudio
, p. 478 - 481 (2018)
[Figure not available: see fulltext.] A new eco-friendly and reliable methodology for the synthesis of 1,2,3,4-tetrahydroquinazolines is proposed. This simple protocol was tested for the continuous synthesis of a small library of 1,2,3,4-tetrahydroquinazo
Dehydrogenation of Nitrogen Heterocycles Using Graphene Oxide as a Versatile Metal-Free Catalyst under Air
Zhang, Jingyu,Chen, Shiya,Chen, Fangfang,Xu, Wensheng,Deng, Guo-Jun,Gong, Hang
supporting information, p. 2358 - 2363 (2017/07/22)
Graphene oxide (GO) has been developed as an inexpensive, environmental friendly, metal-free carbocatalyst for the dehydrogenation of nitrogen heterocycles. Valuable compounds, such as quinoline, 3,4-dihydroisoquinoline, quinazoline, and indole derivatives, have been successfully used as substrates. The investigation of various oxygen-containing molecules with different conjugated systems indicated that both the oxygen-containing groups and large π-conjugated system in GO sheets are essential for this reaction. (Figure presented.).
Highly efficient one-pot synthesis of 2-substituted quinazolines and 4H-benzo[d][1,3]oxazines via cross dehydrogenative coupling using sodium hypochlorite
Maheswari, C. Uma,Kumar, G. Sathish,Venkateshwar,Kumar, R. Arun,Kantam, M. Lakshmi,Reddy, K. Rajender
supporting information; experimental part, p. 341 - 346 (2010/04/28)
This communication describes a catalyst-free synthesis of 2-substituted quinazolines and 4H-benzo[d][1,3]oxazines using commericially available sodium hypochlorite as oxidant. Operational simplicity, mild reaction conditions and the ability to construct structurally diverse 2-quinazolines and 2-substituted 4H-benzo[d][1,3]oxazines by this method render it to be a practical alternative for the synthesis of these heterocycles.
A convenient one-pot procedure for the synthesis of 2-aryl quinazolines using active MnO2 as oxidant
Peng, Yi-Yuan,Zeng, Yuyun,Qiu, Ganyinsheng,Cai, Lisheng,Pike, Victor W.
experimental part, p. 1240 - 1245 (2010/11/18)
(Chemical Equation Presented) A variety of 2-aryl quinazolines were synthesized from the condensation of 2-aminobenzylamines and aryl aldehydes to form 2-aryl-1,2,3,4-tetrahydroquinazolines and subsequent oxidation of the intermediates with MnO2/sub
