501657-49-4

Upstream product

• 91-00-9 Benzhydrylamine 
• 283585-32-0 ((R)-1-Methyl-2-oxo-1,2,3,4-tetrahydro-naphthalen-1-yl)-acetaldehyde 
• 283584-97-4 (S)-4-tert-Butyl-2-[(1S,2S)-2-(dimethyl-phenyl-silanyl)-1-methyl-1,2,3,4-tetrahydro-naphthalen-1-yl]-4,5-dihydro-oxazole 
• 283585-10-4 Dimethyl-[(1R,2S)-1-methyl-1-((E)-2-nitro-vinyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-phenyl-silane 
• 283585-15-9 Dimethyl-[(1R,2S)-1-methyl-1-(2-nitro-ethyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-phenyl-silane 
• 283585-04-6 (1S,2S)-2-(Dimethyl-phenyl-silanyl)-1-methyl-1,2,3,4-tetrahydro-naphthalene-1-carbaldehyde 
• 283585-18-2 (1R,2S)-1-Methyl-1-(2-nitro-ethyl)-1,2,3,4-tetrahydro-naphthalen-2-ol 
• 283585-29-5 (1R,2S)-1-(2-Hydroxy-ethyl)-1-methyl-1,2,3,4-tetrahydro-naphthalen-2-ol 
• 283585-24-0 (3aS,9bR)-9b-methyl-3a,4,5,9b-tetrahydronaphtho[2,1-b]furan-2(1H)-one 
• 154547-92-9 (S)-4-tert-Butyl-2-[(1S,2S)-2-(dimethyl-phenyl-silanyl)-1-methyl-1,2-dihydro-naphthalen-1-yl]-4,5-dihydro-oxazole 
• 154547-98-5 (1S,2S)-2-(Dimethyl-phenyl-silanyl)-1-methyl-1,2-dihydro-naphthalene-1-carbaldehyde 
• 132912-17-5 1-<4'-(S)-tert-butyloxazolin-2'-yl>naphthalene 
• 4024-14-0 1-methyl-2-tetralone 
• 5267-34-5 aminodiphenylmethane hydrochloride 

Relevant academic research and scientific papers

Palladium-catalyzed asymmetric allylic alkylation of α-aryl ketones

Quaternary centers can be created asymmetrically in high enantiomeric excess by the proper choice of ligand and metal cation in the Pd-catalyzed asymmetric allylic alkylation of α-aryl ketones. A broad range of ketone enolates can be tolerated in the reac

Enantioselective synthesis of rigid 2-aminotetralins. Utility of silicon as an oxygen and nitrogen surrogate in the tandem addition reaction

Dimethylphenylsilyllithium undergoes a highly diastereoselective conjugate addition to chiral naphthyloxazoline 11. Electrophilic trapping of the resulting aza-enolate affords the tandem addition product (12) in high yields as a single diastereomer. The silicon, thus incorporated, may be protodesilylated and undergoes a Tamao oxidation to afford the corresponding alcohol. By chemical modification of the oxazoline, both the γ-lactone (28) and the δ-lactone (37) were prepared. Reduction of each lactone followed by oxidation of the ensuing diol gave the keto aldehyde. Double reductive animation of the 1,4-dicarbonyl (from the γ-lactone) allowed the synthesis of two novel hexahydrobenz[e]indoles, 20 and 35. Double reductive amination of the 1,5-dicarbonyl (from the δ-lactone) gave access to two novel octahydrobenzo[f]quinolines, 41 and 43. An unprecedented rearrangement of nitro alcohol 26 into lactone 28 is described and a reasonable mechanism for its formation postulated.