501666-73-5Relevant academic research and scientific papers
Oxidative and dehydrative cyclizations of nitroacetate esters with Mn(OAc)3
Snider, Barry B,Che, Qinglin
, p. 7821 - 7827 (2007/10/03)
Reaction of α-unsubstituted nitroacetates with Mn(OAc)3 gives mixtures of isoxazolines, formed by dehydration to a nitrile oxide that undergoes cycloaddition, and isoxazoline oxides or cyclopropane, formed by oxidative cyclization. Oxidative cyclization is favored with electron-rich alkenes and cycloaddition with the nitrile oxide to give isoxazolines is favored with electron-poor alkenes. On the other hand, α-substituted nitroacetates cannot dehydrate and undergo only radical reactions.
