501676-50-2

Upstream product

• 120-57-0 piperonal 
• 99-91-2 para-chloroacetophenone 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 104-88-1 4-chlorobenzaldehyde 
• 120-58-1 isosafrole 

Downstream Products

• 1376396-02-9 3-(benzo[d][1,3]dioxol-5-yl)-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazole-1-carbaldehyde 
• 1376395-97-9 1-acetyl-3-(benzo[d][1,3]dioxol-5-yl)-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazole 
• 1376396-08-5 3-(benzo[d][1,3]dioxol-5-yl)-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide 
• 1258439-89-2 C₂₂H₁₇ClN₂O₂ 
• 1402415-38-6 C₂₁H₁₈ClN₅O₂S 
• 1402415-45-5 C₂₀H₁₇ClN₆O₂ 

Relevant academic research and scientific papers

Synthesis and biological evaluation of novel aryl-2H-pyrazole derivatives as potent non-purine xanthine oxidase inhibitors

A series of aryl-2H-pyrazole derivatives were synthesized and evaluated for inhibitory activity against xanthine oxidase in vitro as potent xanthine oxidase inhibitors. Among them, 2 aryl-2H-pyrazole derivatives showed significant inhibitory activities against xanthine oxidase. Compound 19 emerged as the most potent xanthine oxidase inhibitor (IC50=9.8 μM) in comparison with allopurinol (IC50=9.5 μM). The docking study revealed that compound 19 might have strong interactions with the active site of xanthine oxidase. This compound is thus a new candidate for further development for the treatment of gout.

One-pot two-step oxidative cleavage of 1,2-arylalkenes to aryl ketones instead of arylaldehydes in an aqueous medium: A complementary approach to ozonolysis

A new approach has been developed for a one-pot and selective oxidative cleavage of aryl- and 1,2-diarylalkenes leading to one-carbon shorter aryl ketones; thereby, providing a complementary approach to classical ozonolysis. The methodology was applicable to diverse aromatic and polyaromaticarylalkenes bearing electron-donating or -withdrawing groups on the aromatic ring. The protocol also provided a useful one-pot oxidative cleavage-condensation sequence, which could potentially have important applications in natural product total synthesis. A one-pot, two-step approach has been achieved for the oxidative cleavage of 1,2-disubstituted arylalkenes into the corresponding aryl ketones instead of arylaldehydes (see scheme; NIS = N-iodosuccinimide; CTAB = cetyltrimethylammonium bromide; PDC/TBHP = pyridinium dichromate/tert-butyl hydroperoxide). The methodology also led to a valuable one-pot oxidative cleavage-condensation reaction that has widespread utility in the total synthesis of natural products.