501682-72-0

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 402-46-0 4-fluorophenylsulphonamide 

Downstream Products

• 501682-74-2 (E)-N,N'-bis(tert-butyloxycarbonyl)-N,N'-bis[(4-fluorophenyl)sulfonyl]-2-butene-1,4-diamine 
• 850334-59-7 N-[(E)-4-bromo-2-butenyl]-N-(tert-butyloxycarbonyl)-(4-fluorophenyl)sulfonamide 
• 918401-81-7 N-[(E)-4-chloro-2-buten-1-yl]-N-(tert-butoxycarbonyl)-(4-fluorophenyl)sulfonamide 
• 850334-23-5 (E,E)-1,6,11-tris[(4-fluorophenyl)sulfonyl]-1,6,11-triazaundeca-3,8-diene 
• 850334-72-4 (E,E)-1,11-bis(tert-butyloxycarbonyl)-1,6,11-tris[(4-fluorophenyl)sulfonyl]-1,6,11-triazaundeca-3,8-diene 
• 918401-72-6 1,6,11-tris[(4-fluorophenyl)sulfonyl]-1,6,11-triazacyclopentadecane 
• 501682-78-6 (E,E,E)-1,6,11-tris[(4-fluorophenyl)sulfonyl]-1,6,11-triazacyclopentadeca-3,8,13-triene 

Relevant academic research and scientific papers

Enantioselective Reductive Divinylation of Unactivated Alkenes by Nickel-Catalyzed Cyclization Coupling Reaction

Catalytic asymmetric dicarbofunctionalization of tethered alkenes has emerged as a promising tool for producing chiral cyclic molecules; however, it typically relies on aryl-tethered alkenes to form benzene-fused compounds. Herein, we report an enantioselective cross-electrophile divinylation reaction of nonaromatic substrates, 2-bromo-1,6-dienes. The approach thus offers a route to new chiral cyclic architectures, which are key structural motifs found in various biologically active compounds. The reaction proceeds under mild conditions, and the use of chiral t-Bu-pmrox and 3,5-difluoro-pyrox ligands resulted in the formation of divinylated products with high chemo-, regio-, and enantioselectivity. The method is applicable for the incorporation of chiral hetero- and carbocycles into complex molecules.

A Radical-Initiated Fragmentary Rearrangement Cascade of Ene-Ynamides to [1,2]-Annulated Indoles via Site-Selective Cyclization

Straightforward access to [1,2]-annulated indoles, key substructures in natural products, is highly desirable yet challenging. Herein, a radical triggered fragmentary cyclization cascade reaction of ene-ynamides is presented, providing a rapid access into [1,2]-annulated indoles by an intermolecular radical addition, intramolecular cyclization, desulfonylative aryl migration, and site-selective C(sp2)-N cyclization sequence. DFT calculations support oxidation of N-centered radical species to cations prior to the C-N bond formation, followed by an unusual aza-Nazarov cyclization.

Reactivity of Arynes for Arene Dearomatization

An unprecedented aryne-mediated dearomatization reaction is described. An aryne intermediate generated from arenesulfonyl ynamide-tethered triynes and tetraynes reacts with both the π-systems of a tethered alkene and the arenesulfonyl group to generate cy

15 and 30-Membered polyolefinic macrocycles. Periphery modification by aromatic nucleophilic substitution of fluorine

Tris[(4-fluorophenyl)sulfonyl]-1,6,11-triazacyclopentadeca-3,8,13-triene is a pivotal 15-membered triolefinic macrocycle from which a vast array of different derivatives are prepared by substitution of fluorine atoms.