501892-90-6

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 3-bromobenzofuran-5-carboxylate is used as a building block for the development of pharmaceuticals, due to its potential applications in creating various biologically active compounds.
Used in Agrochemical Industry:
Methyl 3-bromobenzofuran-5-carboxylate is used as a precursor in the synthesis of agrochemicals, contributing to the development of effective and targeted pest control solutions.
Used in Fine Chemicals Industry:
Methyl 3-bromobenzofuran-5-carboxylate is utilized in the production of other fine chemicals, showcasing its diverse reactivity and versatility in chemical synthesis.
It is important to handle and use Methyl 3-bromobenzofuran-5-carboxylate with proper safety precautions due to its potential hazards and risks associated with handling organic bromine compounds.

Upstream product

• 108763-47-9 5-(methoxycarbonyl)benzo[b]furan 

Downstream Products

• 1005205-60-6 methyl 3-(4-methoxyphenyl)-1-benzofuran-5-carboxylate 
• 1005206-23-4 methyl 3-[4-(methylsulfanyl)phenyl]-1-benzofuran-5-carboxylate 

Relevant academic research and scientific papers

Design, synthesis and structure-activity relationships of 1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3β

Glycogen synthase kinase-3β (GSK-3β) is implicated in abnormal hyperphosphorylation of tau protein and its inhibitors are expected to be a promising therapeutic agents for the treatment of Alzheimer's disease. Here we report design, synthesis and structure-activity relationships of a novel series of oxadiazole derivatives as GSK-3β inhibitors. Among these inhibitors, compound 20x showed highly selective and potent GSK-3β inhibitory activity in vitro and its binding mode was determined by obtaining the X-ray co-crystal structure of 20x and GSK-3β.

2-{3-[4-(Alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3β with good brain permeability

Glycogen synthase kinase 3β (GSK-3β) inhibition is expected to be a promising therapeutic approach for treating Alzheimer's disease. Previously we reported a series of 1,3,4-oxadiazole derivatives as potent and highly selective GSK-3β inhibitors, however,

Azabicyclic compounds for the treatment of disease

The invention provides compounds of Formula I: 1wherein Azabicyclo is 2These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals in which α7 is known to be involved.