501903-57-7

Basic information

• Product Name: 1-(4-bromo-2-fluorophenyl)piperazine
• Synonyms: 1-(4-bromo-2-fluorophenyl)piperazine
• CAS NO: 501903-57-7
• Molecular Weight: 259.121
• Mol File: 501903-57-7.mol

Chemical Properties

• CAS DataBase Reference: 1-(4-bromo-2-fluorophenyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-bromo-2-fluorophenyl)piperazine(501903-57-7)
• EPA Substance Registry System: 1-(4-bromo-2-fluorophenyl)piperazine(501903-57-7)

Safety Data

• Hazardous Substances Data: 501903-57-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-bromo-2-fluorophenyl)piperazine is used as a pharmaceutical intermediate for the development of drugs targeting the central nervous system. Its unique structure allows it to interact with specific receptors and proteins, making it a promising candidate for the treatment of various neurological disorders.
Used in Research and Development:
1-(4-bromo-2-fluorophenyl)piperazine is used as a research compound for studying its psychoactive and other pharmacological properties. This helps scientists understand its potential effects on the human body and how it can be utilized in the development of new medications.
Used in Synthesis of Biologically Active Molecules:
1-(4-bromo-2-fluorophenyl)piperazine is used as a building block for the synthesis of various molecules with biological activity. Its unique structure can be further modified and combined with other chemical groups to create new compounds with potential therapeutic applications.

Upstream product

• 321-23-3 4-bromo-2-fluoronitrobenzene 
• 1163248-77-8 1-[4-(4-bromo-2-fluorophenyl)piperazin-1-yl]-2,2,2-trifluoroethanone 
• 1011-15-0 1-(o-fluorophenyl)piperazine 
• 105931-73-5 1-bromo-3-fluoro-4-iodobenzene 
• 154590-35-9 tert-butyl 4-(4-amino-2-fluorophenyl)piperazine-1-carboxylate 
• 154590-34-8 4-(2-fluoro-4-nitrophenyl)-piperazine-1-carboxylic acid tert butyl ester 
• 369-34-6 3,4-difluoronitrobenzene 
• 367-24-8 4-bromo-2-fluoroaniline 
• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 

Downstream Products

• 1415793-99-5 1-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine 

Relevant articles and documents

2-OXO-THIAZOLE DERIVATIVES AS A2A INHIBITORS AND COMPOUNDS FOR USE IN THE TREATMENT OF CANCERS

The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof. The invention further relates to the use of the compounds of Formula (I) as A2A inhibitors. The invention also relates to the use of the compounds of Formula (I) for the treatment and/or prevention of cancer. The invention also relates to a process for manufacturing compounds of Formula (I).

Thiazolidine derivatives or salts thereof as an active ingredient an inhibitor Pim

PROBLEM TO BE SOLVED: To provide compounds which have excellent Pim inhibitory action and are useful as pharmaceuticals.SOLUTION: A compound is a thiazolidine derivative represented by the general formula (1) in the figure, or a salt thereof. (In the formula, X represents O or S; Rrepresents a hydrogen atom or a Calkyl group; Z, Z, Z, Z, Zand Zeach independently represent CH or N; Y represents an optionally substituted, divalent Caromatic hydrocarbon group or the like; Am represents a disubstituted amino group, or an optionally substituted, nitrogen-containing saturated heterocyclic group; and Rand Reach independently represent a hydrogen atom, a halogen atom, an alkyl group or the like.)

THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS

The disclosure relates to inhibitors of USP28 and/or USP25 useful in the treatment of cancers, inflammation, autoimmune diseases, and infectious diseases, having the Formula (I), where R1, R2, R3, R4, R5, R5', R6, R7, X, m, and n are described herein.

SUBSTITUTED PYRIDOPYRAZINES AS NOVEL SYK INHIBITORS

Provided are pyridopyrazine compounds of formula (1), pharmaceutical compositions thereof and methods of use therefore, wherein R1, R2, R3, R4 and m are as defined in the specification.

Practical method for parallel synthesis of diversely substituted 1-phenylpiperazines

A simple and practical method to prepare 'libraries' of substituted 1-phenylpiperazine building blocks in parallel format has been developed.