501918-63-4Relevant academic research and scientific papers
Regioselective synthesis of 2H-indazoles through Ga/Al- and Al-mediated direct alkylation reactions of indazoles
Lin, Mei-Huey,Liu, Han-Jun,Lin, Wei-Cheng,Kuo, Chung-Kai,Chuang, Tsung-Hsun
, p. 11376 - 11381 (2015)
A procedure has been developed for the regioselective, high yielding synthesis of 2H-indazoles that involves direct alkylation of indazoles with various allyl and benzyl bromides, and α-bromocarbonyl compounds.
One-pot synthesis of new 6-pyrrolyl-N-alkyl-indazoles from reductive coupling of N-alkyl-6-nitroindazoles and 2,5-hexadione
El Ghozlani, Mohamed,Chicha, Hakima,Abbassi, Najat,Chigr, Mohamed,El Ammari, Lahcen,Saadi, Mohamed,Spinelli, Domenico,Rakib, El Mostapha
supporting information, p. 113 - 117 (2015/12/23)
One-pot synthesis of 6-pyrrolyl-N-alkyl-indazoles by the reductive coupling of N-alkyl-6-nitroindazoles and 2,5-hexadione was investigated in the presence of different reducing agents (SnCl2/AcOH and In/AcOH in THF). Indazoles 5a-h and 6a-h wer
Alkylation and reduction of N-alkyl-4-nitroindazoles with anhydrous SnCl2 in ethanol: Synthesis of novel 7-ethoxy-N-alkylindazole derivatives
Abbassi, Najat,Rakib, El Mostapha,Hannioui, Abdellah,Alaoui, Mdaghri,Benchidmi, Mohamed,Essassi, El Mokhtar,Geffkenc, Detlef
experimental part, p. 891 - 900 (2011/05/12)
New series of indazoles substituted at the N-1 and N-2 positions and their 7-ethoxy derivatives have been synthesis starting from alkylation of 4-nitroindazole and reduction of alkyl-nitro-derivatives with anhydrous SnCl2 in ethanol. The structures of the
Selective synthesis of 1 -functionalized-alkyl-1H-indazoles
Hunt, Kevin W.,Moreno, David A.,Suiter, Nicole,Clark, Christopher T.,Kim, Ganghyeok
scheme or table, p. 5054 - 5057 (2009/12/28)
An efficient method for the selective "N1" alkylation of indazoles is described. Use of a-halo esters, lactones, ketones, amides, and bromoacetonitrile provides good to excellent yield of the desired N1 products.
