502133-71-3

Upstream product

• 106-96-7 propargyl bromide 
• 123-54-6 acetylacetone 

Downstream Products

• 1195869-77-2 1-{5-[2-oxo-2-(4-trifluoromethoxyphenyl)ethyl]furan-2-yl}propan-2-one 
• 1195869-65-8 1-{5-[2-(2-benzyloxyphenyl)-2-oxoethyl]furan-2-yl}propan-2-one 
• 1195869-74-9 1-{5-[2-oxo-2-(3-trifluoromethylphenyl)ethyl]furan-2-yl}propan-2-one 
• 1195869-76-1 1-{5-[2-oxo-2-(4-trifluoromethylphenyl)ethyl]furan-2-yl}propan-2-one 
• 1195869-70-5 1-{5-[2-(2-chlorophenyl)-2-oxoethyl]furan-2-yl}propan-2-one 
• 1195869-68-1 1-{5-[2-(4-hydroxyphenyl)-2-oxoethyl]furan-2-yl}propan-2-one 
• 1195869-71-6 1-{5-[2-(3-chlorophenyl)-2-oxoethyl]furan-2-yl}propan-2-one 
• 1195869-58-9 1-[5-(2-oxo-2-(p-tolyl)ethyl)furan-2-yl]propan-2-one 
• 1195869-66-9 1-{5-[2-(2-hydroxyphenyl)-2-oxoethyl]furan-2-yl}propan-2-one 
• 1195869-73-8 1-{5-[2-(4-chlorophenyl)-2-oxoethyl]furan-2-yl}propan-2-one 
• 1195869-56-7 1-[5-(2-oxo-2-(o-tolyl)ethyl)furan-2-yl]propan-2-one 
• 1195869-32-9 1-[5-(2-oxo-2-phenylethyl)-furan-2-yl]propan-2-one 
• 1195869-60-3 1-{5-[2-(4-benzyloxy-2-methylphenyl)-2-oxoethyl]furan-2-yl}propan-2-one 

Relevant academic research and scientific papers

1,3-Diketone-Modified Nucleotides and DNA for Cross-Linking with Arginine-Containing Peptides and Proteins

Linear or branched 1,3-diketone-linked thymidine 5′-O-mono- and triphosphate were synthesized through CuAAC click reaction of diketone-alkynes with 5-azidomethyl-dUMP or -dUTP. The triphosphates were good substrates for KOD XL DNA polymerase in primer extension synthesis of modified DNA. The nucleotide bearing linear 3,5-dioxohexyl group (HDO) efficiently reacted with arginine-containing peptides to form stable pyrimidine-linked conjugates, whereas the branched 2-acetyl-3-oxo-butyl (PDO) group was not reactive. Reaction with Lys or a terminal amino group formed enamine adducts that were prone to hydrolysis. This reactive HDO modification in DNA was used for bioconjugations and cross-linking with Arg-containing peptides or proteins (e.g. histones).

Synthesis of carbazoles based on gold-copper tandem catalysis

An efficient synthetic method for carbazoles has been developed employing diazo anilinoalkynes as substrates. Sequential activation of the orthogonal functional groups embedded in diazo anilinoalkyne substrates by tandem gold-copper catalysis leads to the formation of highly substituted carbazoles. Substrate scope reveals a broad tolerability toward the substitution on aryl groups.

Palladium-catalyzed carbonylative cycloisomerization of γ-propynyl-1,3-diketones: A concise route to polysubstituted furans

(Chemical Equation Presented) Di- and trisubstituted furan derivatives have been efficiently synthesized via palladium(II)-catalyzed intramolecular carbonylative cycloisomerization of γ-propynyl-1,3-diketones with aryl iodides and carbon monoxide. The mec

Copper/silver-cocatalyzed conia-ene reaction of linear β-alkynic β-ketoesters

A novel and general copper/silver catalytic system has been developed for the Conia-ene intramolecular reaction of linear β-alkynic β-ketoesters. In the presence of (CuOTf)2·C 6H6 and AgSbF6 (or AgOAc), a variety of the linear β-alkynic β-ketoesters selectively underwent the Conia-ene intramolecular reaction in moderate to good yields.

Mechanism of the palladium-catalyzed intramolecular hydroalkylation of 7-octene-2,4-dione

Cyclization of (E)-7,8-dideuterio-7-octene-2,4-dione [(E)-1-7,8-d2] catalyzed by PdCl2(CH3CN)2 (2) formed cis-2-acyl-3,4-dideuteriocyclohexanone (cis-3-3,4-d2) in 64% yield as the exclusive isotopomer. This experiment, in conjunction with additional deuterium labeling experiments, was in accord with a mechanism for the conversion of 1 to 3 catalyzed by 2 involving attack of the enol carbon atom on a palladium-complexed olefin followed by palladium migration and protonolysis from a palladium enolate complex. Copyright