502157-83-7

Upstream product

• 629-05-0 n-octyne 
• 615-42-9 1,2-Diiodobenzene 
• 157869-10-8 2-(oct-1-yn-1-yl)aniline 
• 615-43-0 2-iodophenylamine 
• 583-55-1 1-Bromo-2-iodobenzene 
• 121221-93-0 1-bromo-2-oct-1-yn-1-ylbenzene 

Downstream Products

• 1558818-26-0 C₂₃H₂₆O₂ 
• 502157-85-9 1,3,5-triethynyl-2,4,6-tris[(2-(1-octynyl)phenyl)ethynyl]benzene 
• 502157-84-8 1,3,5-tris[(trimethylsilyl)ethynyl]-2,4,6-tris[(2-(1-octynyl)phenyl)ethynyl]benzene 

Relevant academic research and scientific papers

Diaceno[a,e]pentalenes from homoannulations of o-alkynylaryliodides utilizing a unique Pd(OAc)2/n-Bu4NOAc catalytic combination

A heterogeneous catalytic system, Pd(OAc)2/n-Bu4NOAc, for the efficient synthesis of diaceno[a,e]pentalenes via a tandem Pd catalytic cycle is reported. The catalytic partner n-Bu4NOAc played indispensable and versatile ro

Synthesis of tetracyclic chromenones via platinum(ii) chloride catalysed cascade cyclization of enediyne-enones

PtCl2 catalysed cascade cyclization of an enediyne-enone system to afford a tetracyclic chromenone is reported, which proceeds through two consecutive highly regioselective 6-endo-dig cyclizations in a single step with the formation of two new C-C bonds and two new rings in excellent yield. A mechanism for this transformation is proposed based on the isolated intermediates.

C(sp2)-C(sp) and C(sp)-C(sp) Coupling Reactions Catalyzed by Oxime-Derived Palladacycles

Oxime-derived chloro-bridged palladacycle 8a, derived from 4,4′-dichlorobenzophenone, is an efficient pre-catalyst for the copper- and amine-free Sonogashira coupling between terminal acetylenes and aryl iodides and aryl and vinyl bromides achieving turnover numbers (TON) of up to 72000. Catalyst 8a has also been shown as a effective promoter for the sila-Sonogashira coupling between 1-(trimethylsilyl)alkynes and aryl iodides and bromides in the presence of CuI or Bu4NBr as co-catalysts. This complex also catalyzes efficiently the homocoupling reaction (Glaser-type coupling) between 1-alkynes in NMP at room temperature with TONs of up to 1000. All the reactions can be performed under air and employing reagent-grade chemicals under very low loading conditions, which demonstrates the versatility and high activity of oxime-derived palladacycles.

En route to archimedene: Total synthesis of C3h-symmetric [7]phenylene

(Matrix presented) The total synthesis of C3h-symmetric [7]phenylene has been accomplished by triple cobalt-catalyzed cycloisomerization of an appropriate nonayne. Its spectral data are in accord with the expectations for a triply angularly fus