502173-45-7

Basic information

• Product Name: Carbonocyanidic amide, N-(4-methoxyphenyl)- (9CI)
• Synonyms: Carbonocyanidic amide, N-(4-methoxyphenyl)- (9CI)
• CAS NO: 502173-45-7
• Molecular Formula: C9H8N2O2
• Molecular Weight: 176.17
• Mol File: 502173-45-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Carbonocyanidic amide, N-(4-methoxyphenyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Carbonocyanidic amide, N-(4-methoxyphenyl)- (9CI)(502173-45-7)
• EPA Substance Registry System: Carbonocyanidic amide, N-(4-methoxyphenyl)- (9CI)(502173-45-7)

Safety Data

• Hazardous Substances Data: 502173-45-7(Hazardous Substances Data)

Upstream product

• 104-94-9 4-methoxy-aniline 
• 65573-12-8 4-chloro-5H-1,2,3-dithiazole-5-one 
• 4968-41-6 (4-methoxyphenyl)carbamothioyl cyanide 
• 726-11-4 2-(hydroxyimino)-3-oxo-N-(4-methoxyphenyl)butanamide 

Relevant articles and documents

Iodine-DMSO mediated conversion of Narylcyanothioformamides to Narylcyanoformamides and the unexpected formation of 2-cyanobenzothiazoles

Cyanoformamides are ubiquitous as useful components for assembling key intermediates and bioactive molecules. The development of an efficient and simple approach to this motif is a challenge. Herein, we demonstrate the effectiveness of the I2-DMSO oxidative system in the preparation of Narylcyanoformamides from N-arylcyanothioformamides. The synthetic method features mild conditions, broad substrate scope, and high reaction efficiency. Furthermore, this method provides an excellent entry to exclusively afford 2-cyanobenzothiazoles which are useful substrates to access new luciferin analogs. The structures of all new products were elucidated by multinuclear NMR spectroscopy and high accuracy mass spectral analysis. Crystal-structure determination by means of single-crystal X-ray diffraction was carried out on (4-bromophenyl)carbamoyl cyanide, 5,6-dimethoxybenzo[d]thiazole-2- carbonitrile, 5-(benzyloxy)benzo[d]oxazole-2-carbonitrile, 4,7-dimethoxybenzo[d]thiazole-2-carbonitrile, and (5-iodo-2,4-dimethoxyphenyl)carbamoyl cyanide, a key intermediate with mechanistic implications.

Synthesis method of cyano-formamide compound

The invention discloses a synthesis method of a cyano-formamide compound, and relates to the technical field of chemical synthesis. The cyano-formamide compound shown in the formula III is synthesizedfrom a 1-acyl-1-carbamyl oxime compound shown in the fo

A convenient synthesis of symmetrical N,N′-dialkylureas by the reactions of 4-chloro-5H-1,2,3-dithiazol-5-one with alkylamines

Treatment of 4-chloro-5H-1,2,3-dithiazol-5-one with primary and secondary alkylamines (>2 equiv.) in CH2Cl2 at rt afforded symmetrical N,N′-disubstituted ureas in moderate to good yields. Similarly, the reactions with amino acid ester hydrochlorides in the presence of Et3N (>3 equiv.) under the same conditions gave symmetrical ureas.