5023-08-5

Basic information

• Product Name: 4-METHOXYCANTHIN-6-ONE
• Synonyms: 4-METHOXYCANTHIN-6-ONE
• CAS NO: 5023-08-5
• Molecular Formula: C15H10N2O2
• Molecular Weight: 250.256
• Mol File: 5023-08-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-METHOXYCANTHIN-6-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHOXYCANTHIN-6-ONE(5023-08-5)
• EPA Substance Registry System: 4-METHOXYCANTHIN-6-ONE(5023-08-5)

Safety Data

• Hazardous Substances Data: 5023-08-5(Hazardous Substances Data)

Upstream product

• 72755-19-2 9H-β-carboline-1-carboxylic acid ethyl ester 
• 6649-92-9 ethyl 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate 
• 61-54-1 tryptamine 
• 186581-53-3 diazomethane 

Relevant articles and documents

Total synthesis of cordatanine, structural reassignment of drymaritin, and anti-inflammatory activity of synthetic precursor

Abstract In this study, cordatanine, with a canthin-6-one skeleton, was totally synthesized in four steps via a Pictet-Spengler reaction using tryptamine and methyl glyoxylate with a total yield of 8%. The NMR spectra of synthesized cordatanine compared well with those of drymaritin isolated by Hsieh et al., confirming the need to revise the original structural assignment. In addition, kumujian A, a synthetic intermediate, showed significant anti-inflammatory effects, inhibiting both superoxide anion generation (IC50 4.87 μg/mL) and elastase release (IC50 6.29 μg/mL).