5023-72-3

Usage

Uses

Used in Pharmaceutical Industry:
(4-methoxybenzyl)(4-chlorophenyl)sulfane is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to form carbon-sulfur bonds, contributing to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
(4-methoxybenzyl)(4-chlorophenyl)sulfane is used as a building block in the creation of agrochemicals, such as pesticides and herbicides, due to its reactivity and potential to enhance the effectiveness of these products in agricultural settings.
Used in Organic Synthesis:
(4-methoxybenzyl)(4-chlorophenyl)sulfane is used as a reagent in organic synthesis reactions, particularly for the formation of carbon-sulfur bonds, facilitating the production of a wide range of chemical compounds with diverse applications.

Upstream product

• 106-54-7 p-Chlorothiophenol 
• 105-13-5 4-Methoxybenzyl alcohol 
• 19350-72-2 N'-(4-methoxybenzylidene)-4-methylbenzenesulfonohydrazide 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 41866-56-2 1-(4-chloro-benzenesulfonylmethyl)-4-methoxy-benzene 
• 41866-58-4 p-Chlorphenyl-p-methoxybenzylsulfoxid 

Relevant academic research and scientific papers

Dechalcogenization of Aryl Dichalcogenides to Synthesize Aryl Chalcogenides via Copper Catalysis

An application for dechalcogenization of aryl dichalcogenides via copper catalysis to synthesize aryl chalcogenides is disclosed. This approach is highlighted by the practical conditions, broad substrate scope, and good functional group tolerance with several sensitive groups such as aldehyde, ketone, ester, amide, cyanide, alkene, nitro, and methylsulfonyl. Furthermore, the robustness of this methodology is depicted by the late-stage modification of estrone and synthesis of vortioxetine. Remarkably, synthesis of more challenging organic materials with large ring tension under milder conditions and synthesis of some halogen contained diaryl sulfides which could not be synthesized using metal-catalyzed coupling reactions of aryl halogen are successfully accomplished with this protocol.

Synthesis of thioethers via metal-free reductive coupling of tosylhydrazones with thiols

A metal-free procedure for the synthesis of thioethers is described via the base-promoted reductive coupling of tosylhydrazones with thiols through an insertion of a carbene into the S-H bond.

Isotope effects in nucleophilic substitution reactions. IV. The effect of changing a substituent at the α carbon on the structure os SN2 transition states

Kinetic studies, secondary α-deuterium kinetic isotope effects, primary chlorine kinetic isotope effects (1), Hammett ρ values determined by changing the substituent in the nucleophile, and activation parameters have been used to determine the detailed (relative) structures of the transition states for the S2 reactions between para-substituted benzyl chlorides and thiophenoxide ion.A rationale for the U-shaped Hammett ρ plots observed when para-substituted benzyl compounds react with negatively charged nucleophiles is also presented.