502483-92-3Relevant academic research and scientific papers
Mild synthesis of asymmetric 2′-carboxyethyl-substituted fluoresceins
Lukhtanov, Eugeny A.,Vorobiev, Alexei V.
, p. 2424 - 2427 (2008/09/19)
(Chemical Equation Presented) Asymmetric fluoresceins bearing a carboxyethyl group in the chromophoric portion of the dyes were prepared by a reaction of substituted phthalic anhydride with a carboxyethyl substituted resorcinol analogue followed by a condensation with a second resorcinol analogue. In order to avoid an accumulation of symmetric side products, the second step was performed in two substeps: acid-catalyzed formation of a triphenylmethyl intermediate followed by base-catalyzed cyclization which furnished the desired dyes.
