502498-89-7Relevant academic research and scientific papers
The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase
Takle, Andrew K.,Bamford, Mark J.,Davies, Susannah,Davis, Robert P.,Dean, David K.,Gaiba, Alessandra,Irving, Elaine A.,King, Frank D.,Naylor, Antoinette,Parr, Christopher A.,Ray, Alison M.,Reith, Alastair D.,Smith, Beverley B.,Staton, Penelope C.,Steadman, Jon G.A.,Stean, Tania O.,Wilson, David M.
, p. 4373 - 4376 (2008)
Modification of the potent imidazole-based B-Raf inhibitor SB-590885 resulted in the identification of a series of furan-based derivatives with enhanced CNS penetration. One such compound, SB-699393 (17), was examined in vivo to challenge the hypothesis that selective B-Raf inhibitors may be of value in the treatment of stroke.
