5026-65-3

Usage

Uses

Used in Research Applications:
Hexadecyl 3,4,5-trihydroxybenzoate is used as a research chemical for its potential applications in the study of neurodegenerative diseases and cancer. Its multifaceted properties, including antioxidant and anti-inflammatory effects, make it a valuable tool in scientific investigations.
Used in Pharmaceutical Development:
Hexadecyl 3,4,5-trihydroxybenzoate is used as a potential therapeutic agent for its anti-cancer, anti-neurodegenerative, and anti-diabetic properties. Its ability to modulate various biological pathways involved in these conditions positions it as a candidate for the development of new drugs.
Used in Anti-inflammatory Treatments:
In the field of medicine, Hexadecyl 3,4,5-trihydroxybenzoate is used as an anti-inflammatory agent for treating conditions such as arthritis or inflammatory bowel disease. Its capacity to reduce inflammation and alleviate symptoms makes it a promising option for patients suffering from these disorders.
Used in Antioxidant Formulations:
Hexadecyl 3,4,5-trihydroxybenzoate is used as an antioxidant in various formulations, including dietary supplements and skincare products. Its ability to neutralize free radicals and protect cells from oxidative damage contributes to its value in these applications.

InChI:InChI=1/C23H38O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-28-23(27)19-17-20(24)22(26)21(25)18-19/h17-18,24-26H,2-16H2,1H3

Upstream product

• 36653-82-4 1-Hexadecanol 
• 149-91-7 3,4,5-trihydroxybenzoic acid 

Downstream Products

• 1329455-01-7 hexadecyl 3-O-(β-D-glucopyranosyluronate)-4,5-dihydroxybenzoate 
• 1329454-82-1 hexadecyl 3-O-(β-D-glucopyranosyl)-4,5-dihydroxybenzoate 
• 1329454-95-6 hexadecyl 3-O-(methyl-2,3,4-tri-O-acetyl-β-D-glucopyranosyluronate)-4,5-dihydroxybenzoate 
• 1329454-70-7 hexadecyl 3-O-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside)-4,5-dihydroxybenzoate 

Relevant academic research and scientific papers

Design, Synthesis, and Antifungal Activity of Alkyl Gallates Against Plant Pathogenic Fungi In Vitro and In Vivo

A series of alkyl gallates was synthesized by reacting gallic acid with the corresponding alcohols. Their structures were determined on the basis of spectroscopic data, including NMR and MS. The antifungal activities of these compounds against plant pathogenic fungi in vitro and in vivo were assessed.

Evaluation of anti-herpetic and antioxidant activities, and cytotoxic and genotoxic effects of synthetic alkyl-esters of gallic acid

The n-alkyl esters of gallic acid (CAS 138-57-8) have a diverse range of uses as anti-oxidants in food, cosmetics and pharmaceutical industries. Pharmaceutical studies performed with these compounds have found that they have many therapeutic potentialities including anti-cancer, antiviral and antimicrobial properties. However, more interest has been devoted to their antioxidant activity due to the ability to scavenge and reduce reactive oxygen species (ROS) formation. In this study, gallic acid and 14 different alkyl gallates were tested. The cytotoxicity and anti-herpetic (HSV-1, KOS and 29-R strains) activity were studied by using the MTT (3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide) colorimetric assay and the cell viability by using the Trypan blue dye exclusion method. The genotoxicity was studied by the Comet assay and the antioxidant activity by using the DPPH (1,1-diphenyl-2- picrylhydrazyl) radical scavenging and microsomal lipid peroxidation-inhibiting activities. The results showed that all the tested compounds have anti-herpetic activity at non cytotoxic concentrations with selectivity indices (SI = CC 50/EC50) varying from 0.89 to 18.34, depending on the used HSV-1 strain. It was observed that all tested alkyl gallates showed some degree of genotoxicity, at the tested concentrations, except cetyl gallate, at 256.60 μmol/L (p 50 values varying from 17 to 31 μmol/L; and microsomal lipid peroxidation-inhibiting activity with IC50 values varying from 21 to 59 μmol/L. It was observed that the presence of hydroxyl groups in these molecules is important for their pharmacological profile, but the length of the lateral carbonic chain does not have considerable influence.