502607-12-7Relevant articles and documents
N-heterocyclic carbene catalyzed trifluoromethylation of carbonyl compounds
Song, Jinhua J.,Tan, Zhulin,Reeves, Jonathan T.,Gallou, Fabrice,Yee, Nathan K.,Senanayake, Chris H.
, p. 2193 - 2196 (2007/10/03)
(Chemical Equation Presented) A novel N-heterocyclic carbene (NHC) catalyzed trifluoromethylation reaction of carbonyl compounds was discovered. Both enolizable and nonenolizable aldehydes and α-keto esters undergo facile trifluoromethylation with TMSCF3 at room temperature in the presence of only 0.5-1 mol % of the commercially available NHC (1), providing CF3-substituted alcohols in good yields. Selective trifluoromethylation of aldehydes over ketones can be achieved under NHC catalysis. These conditions are mild and simple and tolerate a variety of functional groups.