502627-85-2Relevant academic research and scientific papers
A practical preparation of 5-(ketoaryl)thiazoles
Marcantonio, Karen M.,Frey, Lisa F.,Murry, Jerry A.,Chen, Cheng-Yi
, p. 8845 - 8848 (2002)
This article describes a facile synthesis of 2-substituted-5-(ketoaryl)thiazoles, which are important intermediates for the synthesis of biologically active compounds. A variety of 2-substituted thiazole anions were added to aryl nitriles to provide the desired ketones after aqueous hydrolysis.
Practical synthesis of a highly functionalized thiazole ketone
Frey, Lisa F.,Marcantonio, Karen M.,Chen, Cheng-Yi,Wallace, Debra J.,Murry, Jerry A.,Tan, Lushi,Chen, Weirong,Dolling, Ulf H.,Grabowski, Edward J. J.
, p. 6363 - 6373 (2007/10/03)
Compound 1 is a uniquely substituted ketone prepared via addition of a thiazole anion to an aromatic nitrile in good overall yield. An exploration into the generality of the addition of thiazole anions to nitriles allowed us to make a variety of thiazole ketones in good to excellent yields. The non-odorous thiolate-mediated demethylation reaction used in the synthesis of 1 is also presented.
