502687-31-2

Upstream product

• 994-30-9 triethylsilyl chloride 
• 502687-18-5 (3R,3aR,5S,6R,6aR)-3,6-Bis-(tert-butyl-diphenyl-silanyloxy)-5-triethylsilanyloxy-tetrahydro-furo[3,2-b]furan-2-one 
• 502687-20-9 (3R,3aR,6R,6aR)-3,6-Bis-(tert-butyl-diphenyl-silanyloxy)-5-hydroxy-tetrahydro-furo[3,2-b]furan-2-one 
• 502687-21-0 (3R,3aR,5S,6R,6aR)-3,6-Bis-(tert-butyl-diphenyl-silanyloxy)-2-methylene-5-triethylsilanyloxy-hexahydro-furo[3,2-b]furan 

Downstream Products

• 870700-63-3 (2R,3R,3aR,5S,6R,6aR)-3,6-Bis-(tert-butyl-diphenyl-silanyloxy)-2-iodomethyl-5-triethylsilanyloxy-hexahydro-furo[3,2-b]furan 
• 502687-21-0 (3R,3aR,5S,6R,6aR)-3,6-Bis-(tert-butyl-diphenyl-silanyloxy)-2-methylene-5-triethylsilanyloxy-hexahydro-furo[3,2-b]furan 

Relevant academic research and scientific papers

Halichondrin B: Synthesis of the C1-C22 subunit

Two efficient routes to the C1-C22 subunit of halichondrin B are described. The cage ketal 7, which contains 11 asymmetric centers embedded within the ABCDEF-ring framework, was assembled from (+)-conduritol E (27) in 18 steps and 4% overall yield. In a s

Halichondrin B: Synthesis of a C1-C14 model via desymmetrization of (+)-conduritol E

(Matrix presented) A model C1-C14 segment (1) of halichondrin B was synthesized from (+)-conduritol E (7) in 18 steps and 2.9% overall yield. Key features of the synthesis include the novel ozonolytic desymmetrization of C2-symmetric diol 6, th