50274-07-2 Usage
Uses
1. Used in Pharmaceutical Applications:
N-[5-Chloro-4-(4-chlorobenzoyl)-2-Methylphenyl]-2-hydroxy-3,5-diiodo-benzaMide is used as an impurity in the synthesis of Closantel, a broad-spectrum anthelmintic. Its presence in the synthesis process is crucial for the development of effective treatments against nematode infections.
2. Used in Veterinary Medicine:
In the veterinary industry, N-[5-Chloro-4-(4-chlorobenzoyl)-2-Methylphenyl]-2-hydroxy-3,5-diiodo-benzaMide plays a significant role as an impurity in the production of Closantel. N-[5-Chloro-4-(4-chlorobenzoyl)-2-Methylphenyl]-2-hydroxy-3,5-diiodo-benzaMide contributes to the overall effectiveness of the anthelmintic, providing a valuable tool for the treatment and prevention of nematode infections in animals.
3. Used in Research and Development:
N-[5-Chloro-4-(4-chlorobenzoyl)-2-Methylphenyl]-2-hydroxy-3,5-diiodo-benzaMide is also utilized in research and development for the study of its chemical properties, potential applications, and interactions with other compounds. This knowledge can lead to the discovery of new uses and improvements in the pharmaceutical and veterinary industries.
Check Digit Verification of cas no
The CAS Registry Mumber 50274-07-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,0,2,7 and 4 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 50274-07:
(7*5)+(6*0)+(5*2)+(4*7)+(3*4)+(2*0)+(1*7)=92
92 % 10 = 2
So 50274-07-2 is a valid CAS Registry Number.
50274-07-2Relevant articles and documents
Substituted salicylanilides as inhibitors of two-component regulatory systems in bacteria
Macielag, Mark J.,Demers, James P.,Fraga-Spano, Stephanie A.,Hlasta, Dennis J.,Johnson, Sigmond G.,Kanojia, Ramesh M.,Russell, Ronald K.,Sui, Zhihua,Weidner-Wells, Michele A.,Werblood, Harvey,Foleno, Barbara D.,Goldschmidt, Raul M.,Loeloff, Michael J.,Webb, Glenda C.,Barrett, John F.
, p. 2939 - 2945 (2007/10/03)
A new class of inhibitors of the two-component regulatory systems (TCS) of bacteria was discovered based on the salicylanilide screening hits, closantel (1) and tetrachlorosalicylanilide (9). A systematic SAR study versus a model TCS, KinA/Spo0F, demonstrated the importance of electron- attracting substituents in the salicyloyl ring and hydrophobic groups in the anilide moiety for optimal activity. In addition, derivatives 8 and 16, containing the 2,3-dihydroxybenzanilide structural motif, were potent inhibitors of the autophosphorylation of the KinA kinase, with IC50s of 2.8 and 6.3 μM, respectively. Compound 8 also inhibited the TCS mediating vancomycin resistance (VanS/VanR) in a genetically engineered Enterococcus faecalis cell line at concentrations subinhibitory for growth. Closantel (1), tetrachlorosalicylanilide (9), and several related derivatives (2, 7, 10, 11, 20) had antibacterial activity against the drug-resistant organisms, methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VREF).
