502763-03-3Relevant academic research and scientific papers
A novel intramolecular Diels-Alder approach to securinega alkaloids: Formal synthesis of securinine
Honda, Toshio,Namiki, Hidenori,Kudoh, Mika,Watanabe, Naofumi,Nagase, Hiromasa,Mizutani, Hirotake
, p. 5927 - 5930 (2000)
A formal total synthesis of securinine (1) was achieved by employing an intramolecular Diels-Alder reaction of the enol ester, derived from 2- acetylpyridine and sorbic anhydride, as a key step. (C) 2000 Elsevier Science Ltd.
A formal total synthesis of securinine via an intramolecular [4+2] cycloaddition reaction
Honda, Toshio,Namiki, Hidenori,Kudoh, Mika,Nagase, Hiromasa,Mizutani, Hirotake
, p. 169 - 187 (2007/10/03)
An intramolecular Diels-Alder reaction of the enol ester derived from 2-acetylpyridine and sorbic anhydride gave the cycloaddition product, stereoselectively, which was further converted into the key intermediate for the synthesis of securinine.
