502765-99-3Relevant academic research and scientific papers
Ring-opening of 1-CF3-substituted epoxy ethers with carboxylic, thiocarboxylic, and phosphinic acids in basic medium and in hexafluoro-2-propanol
Iskra, Jernej,Bonnet-Delpon, Daniele,Begue, Jean-Pierre
, p. 3402 - 3410 (2002)
Ring-opening of 1-CF3-substituted epoxy ethers with carboxylic acids was achieved in Et3N as solvent, and α-CF3-substituted acyloins and corresponding esters were obtained in good yields. In hexafluoro-2-propanol (HFIP) as solvent, the carboxylic acids acted as nucleophiles, and a-carbonyloxy trifluoromethyl ketones were isolated in good yields. After reduction, CF3-substituted glycols were obtained as monoesters on one or the other hydroxy group. This reaction also allowed the preparation of α-carbonylsulfanyl- and α-phosphoryloxy trifluoromethyl ketones and corresponding alcohols. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.
