502841-05-6Relevant academic research and scientific papers
2-Aryl-4-azido-3-(bromo/iodo)quinolines as substrates for the synthesis of primary 4-amino-2,3-disubstituted quinoline derivatives
Mphahlele, Malose J.,Mtshemla, Vathiswa
experimental part, p. 1343 - 1350 (2009/04/07)
(Chemical Equation Presented) Staudinger reaction of the 2-aryl-4-azido-3-bromoquinolines and 2-aryl-4-azido-3-iodoquinolines with triphenyl phosphine in refluxing tetrahydrofuran afforded series of 2-aryl-3-halogeno-4-(triphenylphosphoranylideneamino)quinolines. The latter were, in tum, hydrolyzed to the corresponding primary 4-amino-2-aryl-3-(bromo/ iodo)quinolines using 80% acetic acid under reflux. Tetrakis(triphenylphosphine) palladium(0)-catalyzed Suzuki reaction of the 2-aryl-3-iodo-4- (triphenylphosphoranylideneamino)quinolines with phenylboronic acid in dimethyl formamide in the presence of 2 M K2CO3 followed by hydrolysis of the incipient 2,3-diaryl-4-(triphenylphosphoranylideneamino) quinolines with 80% acetic acid afforded the 4-amino-2,3-diarylquinolines.
Synthesis and further studies of chemical transformation of the 2-aryl-3-halogenoquinolin-4(1H)-one derivatives
Mphahlele, Malose J.,Nwamadi, Mutshinyalo S.,Mabeta, Peace
, p. 255 - 260 (2007/10/03)
The C-3 brominated and iodinated derivatives were prepared from the corresponding 2-arylquinolin-4(1H)-ones and their NMe-4-oxo derivatives using pyridinium tribromide in acetic acid or iodine-Na2CO3 mixture in THF. The results of fu
Solution phase, solid state and computational structural studies of the 2-aryl-3-bromoquinolin-4(1H)-one derivatives
Mphahlele, Malose J.,Fernandes, Manuel A.,El-Nahas, Ahmed M.,Ottosson, Henrik,Ndlovu, Stephen M.,Sithole, Happy M.,Dladla, Bongumusa S.,De Waal, Danita
, p. 2159 - 2164 (2007/10/03)
The structures of the potentially tautomeric 2-aryl-3-bromoquinolin-4(1H)-ones were studied using spectroscopic (NMR, IR and mass), X-ray crystallographic and quantum chemical calculations. These systems are found to exist in solution (1H NMR,
