5029-61-8

Usage

Uses

Used in Organic Synthesis:
2-BROMO-4'-HYDROXY-3'-NITROACETOPHENONE is used as a reagent in organic synthesis for its ability to participate in a variety of chemical reactions, facilitating the creation of complex organic molecules.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 2-BROMO-4'-HYDROXY-3'-NITROACETOPHENONE is used as an intermediate in the synthesis of various drugs, contributing to the development of new medications with potential therapeutic benefits.
Used in Agrochemical Production:
Similarly, in the agrochemical sector, 2-BROMO-4'-HYDROXY-3'-NITROACETOPHENONE serves as an intermediate, playing a crucial role in the synthesis of compounds used in agriculture to protect crops and enhance yields.
Used in Chemical Research:
2-BROMO-4'-HYDROXY-3'-NITROACETOPHENONE is utilized in the field of chemical research as a tool to explore and develop new chemical reactions, expanding the understanding of organic chemistry and its applications.
Used in Therapeutic Agent Development:
Due to its potential biological activities, 2-BROMO-4'-HYDROXY-3'-NITROACETOPHENONE is also used in the research and development of new therapeutic agents, with the aim of discovering novel treatments for various diseases and conditions.

InChI:InChI=1/C8H6BrNO4/c9-4-8(12)5-1-2-7(11)6(3-5)10(13)14/h1-3,11H,4H2

Upstream product

• 6322-56-1 4'-hydroxy-3'-nitroacetophenone 
• 2491-38-5 2-bromo-1-(4'-hydroxyphenyl)-1-ethanone 

Downstream Products

• 870521-02-1 {4-[4-(3-amino-4-hydroxy-phenyl)-thiazol-2-ylmethoxy]-2-methyl-phenoxy}-acetic acid ethyl ester 

Relevant academic research and scientific papers

Formoterol important intermediate and synthesis method thereof

The invention discloses a formoterol important intermediate and a synthesis method thereof. 2-bromo-4'-hydroxyacetophenone is used as a raw material. The synthesis method comprises the following steps: dissolving the raw material in concentrated sulfuric acid, adding nitric acid to obtain an intermediate I, dissolving the intermediate I in dichloromethane, adding tert-butyl dimethyl chlorosilane and triethylamine to obtain an intermediate II, dissolving the intermediate II in anhydrous tetrahydrofuran, adding (R)-2-methyl-CBS-oxazboroline and borane-tetrahydrofuran to obtain a chiral intermediate III, dissolving the intermediate III in anhydrous 1,4-dioxane, and adding sodium methoxide to obtain the final product. The synthesis method has the advantages of low cost, simple operation process, low synthesis difficulty and high product yield.

Synthesis and biological evaluation of novel SIPI-7623 derivatives as farnesoid X receptor (FXR) antagonists

Most of reported steroidal FXR antagonists are restricted due to low potency. We described the design and synthesis of novel nonsteroidal scaffold SIPI-7623 derivatives as FXR antagonists. The most potent compound A-11 (IC50 = 7.8 ± 1.1 μM) showed better activity compared to SIPI-7623 (IC50 = 40.8 ± 1.7 μM) and guggulsterone (IC50 = 45.9 ± 1.1 μM). Docking of A-11 in FXR’s ligand-binding domain was also studied.

Electrophilic tetraalkylammonium nitrate nitration. II. Improved anhydrous aromatic and heteroaromatic mononitration with tetramethylammonium nitrate and triflic anhydride, including selected microwave examples

A new one-pot nitration employing tetramethylammonium nitrate and trifluoromethanesulfonic anhydride in dichloromethane to provide a ready source of the nitronium triflate nitrating agent is presented. Rapid and selective nitration with a variety of aromatic and heteroaromatic substrates is achieved resulting in the synthesis of several novel organic compounds. A distinct advantage is the removal of undesired byproducts by aqueous workup. This very mild nitration permits large-scale syntheses and gives high isolated product yields that often require no further purification. This tetramethylammonium nitrate-based nitration also has been applied to microwave-assisted conditions, and the results with several compounds are outlined.