502916-45-2Relevant academic research and scientific papers
An Efficient One-Pot Synthesis and Anticancer Activity of 4'-Substituted Flavonoids
Wang,Liu,Zhang
, p. 1036 - 1041 (2018)
A number of 4'-substituted (R = H, Me, Cl, F) flavone derivatives is synthesized from 2-hydroxyacetophenones using the modified Baker–Venkataraman reaction. Compound [3-(4-fluorobenzoyl)-5- hydroxy-4'-fluoroflavone] was synthesized for the first time with the yield of 12%. Antiproliferative assays indicate that the synthesized flavones with F substituent at the 4' position demonstrate higher activity than the other flavone derivatives, particularly against HeLa and MCF-7 with the IC50 9.5 and 2.7 μM, respectively.
3-Aroyl-5-hydroxyflavones: Synthesis and transformation into aroylpyrazoles
Pinto, Diana C. G. A.,Silva, Artur M. S.,Almeida, Lucia M. P. M.,Cavaleiro, Jose A. S.,Elguero, Jose
, p. 3807 - 3815 (2007/10/03)
Treatment of 3-aroyl-5-benzyloxyflavones 4a-e with hydrazine afforded 3,5-diaryl-4-(2-benzyloxy-6-hydroxybenzoyl)pyrazoles 5a-e, together with 4-aroyl-5-aryl-3-(2-benzyloxy-6- hydroxyphenyl)pyrazoles 6a-e as minor products. The structures of all new compounds have been established by extensive NMR studies and the reaction mechanisms are discussed. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.
