502929-74-0

Upstream product

• 621-84-1 O-benzyl carbamate 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 1255215-23-6 (S)-benzyl 1-(4-chlorophenyl)-3-oxopropylcarbamate 
• 1322693-73-1 (S)-benzyl ((1-benzyl-1H-pyrrol-2-yl)(4-chlorophenyl)methyl)carbamate 
• 1402850-94-5 benzyl (2S,3R)-6-methyl-3-nitro-2-[4-chlorophenyl]-3,4-dihydropyridine-1(2H)-carboxylate 
• 1542236-22-5 C₂₀H₁₉ClN₂O₄ 
• 1542236-35-0 C₂₀H₁₉ClN₂O₄ 
• 1374450-34-6 (R)-tert-butyl 1-((S)-(benzyloxycarbonylamino)(4-chlorophenyl)methyl)-6-bromo-3-oxo-1,3-dihydroisobenzofuran-1-carboxylate 
• 1374450-24-4 (R)-tert-butyl 1-((S)-(benzyloxycarbonylamino)(4-chlorophenyl)methyl)-3-oxo-1,3-dihydroisobenzofuran-1-carboxylate 
• 1283136-57-1 benzyl (1S,2R)-1-(4-chlorophenyl)-2-formyl-3-methylbutylcarbamate 

Relevant academic research and scientific papers

One-pot catalytic enantioselective synthesis of tetrahydropyridines via a nitro-mannich/hydroamination cascade

The highly enantioselective preparation of synthetically useful tetrahydropyridine derivatives employing a one-pot nitro-Mannich/hydroamination cascade is reported. This approach utilizes an asymmetric organocatalytic nitro-Mannich reaction followed by a gold-catalyzed alkyne hydroamination/ isomerization sequence that yields the desired tetrahydropyridines in good yields and high diastereo- and enantioselectivities.

Asymmetric synthesis of maraviroc (UK-427,857)

The asymmetric synthesis of Maraviroc (UK-427,857), a chemochine receptor 5 (CCR-5) receptor antagonist, based on an expeditious organocatalytic enantioselective assembly of the chiral βamino aldehyde key fragment is presented. The reactions were performed on a gram-scale and allow for the rapid construction of new Maraviroc analogues.