503004-67-9Relevant academic research and scientific papers
Catalyst-controlled asymmetric synthesis of fostriecin and 8-epi-fostriecin
Maki, Keisuke,Motoki, Rie,Fujii, Kunihiko,Kanai, Motomu,Kobayashi, Takayasu,Tamura, Shinri,Shibasaki, Masakatsu
, p. 17111 - 17117 (2007/10/03)
Catalytic asymmetric synthesis of the natural antibiotic fostriecin (CI-920) and its analogue 8-epi-fostriecin and evaluation of their biological activity are described. We used four catalytic asymmetric reactions to construct all of the chiral centers of
Formal catalytic asymmetric total synthesis of fostriecin.
Fujii, Kunihiko,Maki, Keisuke,Kanai, Motomu,Shibasaki, Masakatsu
, p. 733 - 736 (2007/10/03)
The common synthetic intermediate of a potent and promising anticancer agent, fostriecin, was synthesized using a unique method that combines four catalytic asymmetric reactions as shown above.
