503039-46-1Relevant academic research and scientific papers
Histone deacetylase 6 inhibitor and preparation method and application thereof
-
Paragraph 0084; 0089-0090, (2020/11/12)
The invention discloses a histone deacetylase 6 inhibitor and a preparation method and application thereof. The histone deacetylase 6 inhibitor has a structure as shown in the following general formula (I). The invention further provides a preparation method of the compound and application of the compound in preparation of drugs for preventing or treating diseases related to HDAC6 activity or abnormal expression.
NOVEL N-(2-AMINOPHENYL)BENZAMIDE DERIVATIVE HAVING AN UREA STRUCTURE
-
Page/Page column 16-17, (2009/10/18)
The present invention relates to a study on the sy nthesis of a novel N-(2-aminophenyl)benzamide derivativ e having an urea structure and represented by the genera l formula (1); and the utilization of a pharmacological effect of the derivative. A compoun
4-(Heteroarylaminomethyl)-N-(2-aminophenyl)-benzamides and their analogs as a novel class of histone deacetylase inhibitors
Frechette, Sylvie,Leit, Silvana,Woo, Soon Hyung,Lapointe, Guillaume,Jeannotte, Guillaume,Moradei, Oscar,Paquin, Isabelle,Bouchain, Giliane,Raeppel, Stephane,Gaudette, Frederic,Zhou, Nancy,Vaisburg, Arkadii,Fournel, Marielle,Yan, Pu Theresa,Trachy-Bourget, Marie-Claude,Kalita, Ann,Robert, Marie-France,Lu, Aihua,Rahil, Jubrail,Robert MacLeod,Besterman, Jeffrey M.,Li, Zuomei,Delorme, Daniel
, p. 1502 - 1506 (2008/09/19)
The synthesis and biological evaluation of a variety of 4-(heteroarylaminomethyl)-N-(2-aminophenyl)-benzamides and their analogs is described. Some of these compounds were shown to inhibit HDAC1 with IC50 values below the micromolar range, indu
Inhibitors of histone deacetylase
-
, (2008/06/13)
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
Inhibitors of histone deacetylase
-
, (2008/06/13)
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
Inhibitors of histone deacetylase
-
, (2008/06/13)
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
