503155-50-8Relevant academic research and scientific papers
Stereoselective synthesis of substituted pyrrolidines by a domino Michael addition/carbocyclization reaction
Denes, Fabrice,Chemla, Fabrice,Normant, Jean F.
, p. 3536 - 3542 (2002)
The domino 1,4-addition/carbocyclization/functionalization reaction of Michael acceptor 3 with mixed copper/zinc reagents allows the totally diastereoselective formation of 3,4-disubstituted-3-carbomethoxypyrrolidines in a three-component one-pot sequence. ( Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002).
Synthesis of 2-Benzazepines from Benzylamines and MBH Adducts under Rhodium(III) Catalysis via C(sp2)-H Functionalization
Pandey, Ashok Kumar,Han, Sang Hoon,Mishra, Neeraj Kumar,Kang, Dahye,Lee, Suk Hun,Chun, Rina,Hong, Sungwoo,Park, Jung Su,Kim, In Su
, p. 742 - 746 (2018)
The rhodium(III)-catalyzed cross-coupling reaction between commercially available benzylamines and Morita-Baylis-Hillman (MBH) adducts is described. This protocol provides a facile access to various 2-benzazepine derivatives via the C(sp2)-H activation of N-allylated benzylamines and subsequent intramolecular olefin insertion followed by N-allylation reaction. A range of substrates has been used, and a high level of chemoselectivity as well as functional group tolerance was observed. To gain mechanistic insight of this transformation, DFT calculations were also performed.
