503183-58-2Relevant academic research and scientific papers
Pyrazole compounds
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, (2008/06/13)
Pharmaceutical compositions and compounds are provided. The compounds of the invention demonstrate anti-proliferative activity, and may promote apoptosis in cells lacking normal regulation of cell cycle and death. In one embodiment of the invention, pharmaceutical compositions of the compounds in combination with a physiologically acceptable carrier are provided. The pharmaceutical compositions are useful in the treatment of hyperproliferative disorders, which disorders include tumor growth, lymphoproliferative diseases, angiogenesis. The compounds of the invention are substituted pyrazoles and pyrazolines.
Addition reactions of 5-aminobenzotriazoles with dimethyl acetylenedicarboxylate (DMAD). Formation of (Z/E) Michael adducts, (benzotriazol-5-yl)-2-pyridones, a triazolo-9,10-dihydrobenzoazepine and a triazolo-2-oxindole
Sanna, Paolo,Nuvole, Antonio,Sequi, Piera Attilia,Paglietti, Giuseppe
, p. 259 - 280 (2007/10/02)
5-Aminobenzotriazoles (1a-d) reacted with DMAD to give the regioselective Michael adducts (Z)-(2a-d), accompanied with (benzotriazol-5-yl)-2-pyridones (3b-d), and in one case (2c) with the triazolo-9,10-dihydrobenzoazepine (4).Cyclisation of the adducts (Z)-(2b-d) in Dowtherm gave the triazoloquinolinones (6b-d), which were converted into chloro derivatives (9b-d), in turn hydrolysed and decarboxylated to 9-chloro-1(2)-methyltriazoloquinolines (11c-d).Compound (1c) in refluxing acetonitrile with DMAD undergoes unusual cyclisation into triazolo-2-oxindole (5), then converted into 2-methyltriazolocarbostyril-9-carboxylate (17).
