50324-58-8Relevant academic research and scientific papers
Catalytic alkylation of methyl-N-heteroaromatics with alcohols
Blank, Benoit,Kempe, Rhett
supporting information; experimental part, p. 924 - 925 (2010/03/31)
(Chemical Equation Presented) A novel catalytic C-C coupling reaction in which N-heteroaromatic-substituted methyl groups are efficiently alkylated using primary alcohols is introduced. The synthesis protocol is based on iridium catalysts and most likely relies on the borrowing hydrogen or hydrogen autotransfer mechanism. A variety of substrate combinations can readily be employed in this reaction, including pyrimidines, pyrazines, pyridazines, and even fairly activated 2- and 4-picolines. Copyright
