503300-10-5Relevant academic research and scientific papers
A practicable environmentally benign one-pot synthesis of 2-arylbenzofurans at room temperature
Liao, Lian-Yan,Shen, Gang,Zhang, Xue,Duan, Xin-Fang
, p. 695 - 701 (2012)
An environmentallyfriendly one-pot synthesis of 2-arylbenzofurans under ambient temperature has been developed. It features an ortho-hydroxyl group assisted Wittig reaction of substituted salicylaldehyde followed by an in situ oxidative cyclization. Its advantages include readily available and non-hazardous materials, benign reaction conditions (room temperature, green solvent and one-pot manner), easy work-up and high overall yields. Utilizing this methodology, various 2-aryl-benzofurans including four natural products have been synthesized. The Royal Society of Chemistry 2012.
