503306-62-5Relevant academic research and scientific papers
Reaction of indolin-2-ones with cerium(IV) ammonium nitrate
Escolano, Carmen,Vallverdú, Lluís,Jones, Keith
, p. 9541 - 9545 (2002)
The reaction of indolin-2-ones with CAN is studied. When the reaction is carried out in an alcohol as solvent, 3-alkoxyindolin-2-ones are obtained in very good yields. If a non-nucleophilic solvent is used (THF, acetonitrile) 3-nitroxy derivatives are isolated. If the aromatic ring bears an electron-donating group, reactions are accompanied by aromatic ring nitration.
Electrochemical Umpolung C-H Functionalization of Oxindoles
Pastor, Miryam,Vayer, Marie,Weinstabl, Harald,Maulide, Nuno
, p. 606 - 612 (2022/01/12)
Herein, we present a general electrochemical method to access unsymmetrical 3,3-disubstituted oxindoles by direct C-H functionalization where the oxindole fragment behaves as an electrophile. This Umpolung approach does not rely on stoichiometric oxidants and proceeds under mild, environmentally benign conditions. Importantly, it enables the functionalization of these scaffolds through C-O, and by extension to C-C or even C-N bond formation.
