503310-57-4

Usage

Uses

Used in Pharmaceutical Industry:
1,2,5-Thiadiazolidine-2-carboxylic acid, methyl ester, 1,1-dioxide is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to undergo multiple chemical reactions, leading to the formation of new compounds with potential therapeutic properties.
Used in Organic Synthesis:
In the field of organic synthesis, 1,2,5-Thiadiazolidine-2-carboxylic acid, methyl ester, 1,1-dioxide serves as a valuable building block for the creation of diverse organic compounds. Its reactivity and stability, enhanced by the 1,1-dioxide group, allow for the development of novel molecules with potential applications in various industries.

Upstream product

• 503310-46-1 5-benzyl-1,1-dioxo-1λ⁶-[1,2,5]thiadiazolidine-2-carboxylic acid methyl ester 
• 29684-56-8 Burgess Reagent 
• 141-43-5 ethanolamine 

Relevant academic research and scientific papers

New uses for the Burgess reagent in chemical synthesis: Methods for the facile and stereoselective formation of sulfamidates, glycosylamines, and sulfamides

Although the Burgess reagent (methoxycarbonylsulfamoyltriethylammonium hydroxide, inner salt) has found significant use in chemical synthesis as a dehydrating agent, almost no work has been directed towards its potential in other synthetic applications. As this article will detail, we have found that the Burgess reagent is remarkably effective at accomplishing a number of non-dehydrative synthetic tasks when applied to appropriate substrates, such as the formation of sulfamidates from 1,2-diols or epoxyalcohols, α- and β-glycosylamines from carbohydrates, and cyclic sulfamides from 1,2-aminoalcohols. Beyond delineating the power of these new reaction manifolds, we also describe the construction of a group of alternative Burgess-type reagents that extends the scope of these new reactions even further.

Synthesis of non-symmetrical sulfamides using burgess-type reagents

A practical and high-yielding method for the efficient, one-step synthesis of diverse classes of N,N′-differentiated sulfamides employs a wide range of amino alcohols and simple amines using Burgess-type reagents. This methodology extends the application

A new method for the synthesis of nonsymmetrical sulfamides using Burgess-type reagents

A practical and high-yielding method for the efficient, one-step synthesis of diverse classes of N,N′-differentiated sulfamides has been developed from a wide range of amino alcohols and simple amines using Burgess-type reagents (see scheme). This method