503311-60-2Relevant academic research and scientific papers
Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
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Page/Page column 32, (2008/06/13)
Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
Preparation and Functionalization of a Range of Main-Group Trifluoropropynyl Organometallic Compounds: The Application of Metalloid-Directed Carbolithiation to the Selective Synthesis of Novel Fluorocarbon Fragments
Brisdon, Alan K.,Crossley, Ian R.,Pritchard, Robin G.,Sadiq, Ghazala,Warren, John E.
, p. 5534 - 5542 (2008/10/09)
The reaction of 1,1,1,3,3-pentafluoropropane (CF3CH 2CF2H, HFC-245fa) with 3 equiv of n-butyllithium at -10 °C leads to the generation of trifluoropropynyllithium in excellent yields. This reagent reacts readily with a range of group 14 electrophiles R 4-n-EXn (R = Ph, Et; E = C, Si, Ge, Sn, Pb; X = Cl, Br) to yield the organometalloid trifluoropropynyl compounds R 4-nE(C≡CCF3)n. Three of these compounds, Ph3EC≡CCF3 (E = C, Si, Ge), have been crystallographically characterized, representing the first such study of these materials. The silane Ph3SiC≡CCF3 has been derivatized by reaction with LiAlH4 and a range of organolithium reagents (RLi, R = n-Bu, Ph, t-Bu) to afford a new series of β-CF 3-substituted vinylsilanes of the type Ph3SiCH=C(CF 3)R, with predominantly E geometry at the double bond. In the cases R = n-Bu, t-Bu, and Ph, these materials have been crystallographically characterized. Additionally, a remarkably facile cyclization pathway for Ph 3Si≡CCF3, initiated by t-BuLi, that yields the respective gem-difluorocyclopropene has been explored and is described in detail, along with its extension to a number of other systems.
Hydrofluorocarbon 245fa: A versatile new synthon in alkyne chemistry
Brisdon, Alan K.,Crossley, Ian R.
, p. 2420 - 2421 (2007/10/03)
The CFC replacement 1,1,1,3,3-pentafluoropropane (HFC 245fa) has been established as a convenient source of trifluoropropynyllithium under mild conditions; a range of novel and known trifluoropropynyl-containing systems has been prepared in a one-pot procedure.
