503313-12-0

Basic information

• Product Name: Thiocarbonic acid O-[(1S,2S,3S,5S,8S,10S,14S)-10-(diethyl-isopropyl-silanyloxy)-5,14-dihydroxy-8,12,15,15-tetramethyl-4-methylene-tricyclo[9.3.1.0^3,8]pentadec-11-en-2-yl] ester O-phenyl ester
• CAS NO: 503313-12-0
• Molecular Weight: 600.935
• Mol File: 503313-12-0.mol

Chemical Properties

• CAS DataBase Reference: Thiocarbonic acid O-[(1S,2S,3S,5S,8S,10S,14S)-10-(diethyl-isopropyl-silanyloxy)-5,14-dihydroxy-8,12,15,15-tetramethyl-4-methylene-tricyclo[9.3.1.0^3,8]pentadec-11-en-2-yl] ester O-phenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Thiocarbonic acid O-[(1S,2S,3S,5S,8S,10S,14S)-10-(diethyl-isopropyl-silanyloxy)-5,14-dihydroxy-8,12,15,15-tetramethyl-4-methylene-tricyclo[9.3.1.0^3,8]pentadec-11-en-2-yl] ester O-phenyl ester(503313-12-0)
• EPA Substance Registry System: Thiocarbonic acid O-[(1S,2S,3S,5S,8S,10S,14S)-10-(diethyl-isopropyl-silanyloxy)-5,14-dihydroxy-8,12,15,15-tetramethyl-4-methylene-tricyclo[9.3.1.0^3,8]pentadec-11-en-2-yl] ester O-phenyl ester(503313-12-0)

Safety Data

• Hazardous Substances Data: 503313-12-0(Hazardous Substances Data)

Upstream product

• 1005-56-7 phenylcarbonochloridothioate 
• 444578-25-0 Taxa-4(20),11(12)-dien-10β-tert-diethyl-iso-propylsilyloxy-2α,5α,14τriol 

Relevant articles and documents

Studies on taxol biosynthesis. Preparation of 5α-acetoxytaxa-4(20),11-dien-2α,10β-diol derivatives by deoxygenation of a taxadiene tetra-acetate obtained from Japanese yew

The putative metabolite, 5α-acetoxytaxa-4(20),11-dien-2α,10β-diol (7), which is a promising candidate as a biosynthetic pathway triol in taxol biosynthesis, has been prepared by Barton deoxygenation of the C-14-hydroxyl group of a differentially protected derivative of natural 2α,5α,10β-triacetoxy-14β-(2-methyl)-butyryloxytaxa-4 (20),11-diene (8), a major taxoid metabolite isolated from Japanese Yew heart wood. The synthetic protocol devised, is amenable for the preparation of isotopically labeled congeners that will be useful to probe further intermediate steps in the biosynthesis of taxol.