50335-03-0 Usage
Description
Chaetoglobosin A (50335-03-0) is a cytochalasin analog which targets filamentous actin. Displays cytotoxic effects against human colorectal HCT116 cells, IC50=3.15 μM.1 Preferentially induces apoptosis in chronic lymphocytic leukemia cells via targeting the cytoskeleton.2 Enhances the fibrinolytic activity of vascular endothelial cells.3
Occurrence
A complex macrocyclic alkaloid, this base has been isolated from Diplodia rnacrospora. Chaetoglobosin A possesses the property of inhibiting growth
in wheat coleoptiles.
Uses
Chaetoglobosin A is a mycotoxic cytochalasan compound.
Definition
ChEBI: A cytochalasan alkaloid isolated from Chaetomium globosum and Calonectria morganii.
References
1) Li et al. (2014), Chaetoglobosins from Chaetomium globosum, an endophytic fungus in Ginkgo biloba, and their phytotoxic and cytotoxic activities; J. Agric. Food Chem., 62 3734
2) Knudsen et al. (2014), Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton; Leukemia, 28 1289
3) Shinohara et al. (2000), Enhancement of fibrinolytic activity of vascular endothelial cells by chaetoglobosin A, crinipellin B, geodin and triticone B; J. Antibiot. (Tokyo), 53 262
Check Digit Verification of cas no
The CAS Registry Mumber 50335-03-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,0,3,3 and 5 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 50335-03:
(7*5)+(6*0)+(5*3)+(4*3)+(3*5)+(2*0)+(1*3)=80
80 % 10 = 0
So 50335-03-0 is a valid CAS Registry Number.
InChI:InChI=1/C32H36N2O5/c1-17-8-7-10-22-29-31(4,39-29)19(3)27-24(15-20-16-33-23-11-6-5-9-21(20)23)34-30(38)32(22,27)26(36)13-12-25(35)28(37)18(2)14-17/h5-7,9-14,16-17,19,22,24,27-29,33,37H,8,15H2,1-4H3,(H,34,38)/b10-7+,13-12+,18-14+/t17-,19-,22-,24-,27-,28+,29-,31+,32+/m0/s1
