50337-25-2

Upstream product

• 169262-39-9 2-phenyl-2-(2-tosyloxyethyl)-1,3-dioxolane 
• 5764-85-2 Ethyl 3-hydroxy-3-phenylpropanoate 
• 4850-49-1 1-phenyl-1,3-propanediol 
• 51699-49-1 3-hydroxy-3-phenylpropyl 4-methylbenzenesulfonate 

Relevant academic research and scientific papers

Pd-catalyzed kinetic resolution of benzylic alcohols: A practical synthesis of (R)-tomoxetine and (S)-fluoxetine hydrochlorides

A convenient synthetic route to (R)-tomoxetine hydrochloride (90% ee) and (S)-fluoxetine hydrochloride (84% ee) is described. (S)-3-Phenyl-3-hydroxypropyl p-toluenesulphonate, the key intermediate, is obtained by the oxidative kinetic resolution of the corresponding racemic 3-phenyl-3-hydroxypropyl p-toluenesulphonate using (-)-sparteine/Pd(II)/O2 (1 atm) catalytic system.

Autocatalytic decomposition of a β-tosyloxyketone acetal as an acid amplifier

By the action of a small amount of an acid, 2-phenyi-2-(2tosyloxyethyl)-1,3-dioxolane decomposed to give p-toluenesulfonic acid resulting in the proliferation of acid molecules. The decomposition manner was stepwise in solution state and autocatalytic in polymer film. The sensitivity of an acidcatalyzed photoimaging material was enhanced by 10 times upon the addition of the above compound due to the acid proliferation.