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1-(4-hydroxy-4-methylcyclohexyl)ethan-1-one is a chemical compound with the molecular formula C9H16O2. It is a ketone derivative featuring a cyclohexane ring with a methyl group at the 4-position and a hydroxyl group at the same position, connected to an ethanone (acetone) moiety. 1-(4-hydroxy-4-methylcyclohexyl)ethan-1-one is known for its unique structure and potential applications in various chemical and pharmaceutical industries. It is often used as an intermediate in the synthesis of more complex organic compounds and may have potential applications in the development of new drugs or materials. Due to its specific functional groups, it can participate in various chemical reactions, such as oxidation, reduction, and substitution, making it a versatile building block in organic chemistry.

5034-20-8

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5034-20-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 5034-20-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,0,3 and 4 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 5034-20:
(6*5)+(5*0)+(4*3)+(3*4)+(2*2)+(1*0)=58
58 % 10 = 8
So 5034-20-8 is a valid CAS Registry Number.

5034-20-8Downstream Products

5034-20-8Relevant academic research and scientific papers

Synthesis and biological evaluation of 4-(pyridin-4-oxy)-3-(3,3-difluorocyclobutyl)-pyrazole derivatives as novel potent transforming growth factor-β type 1 receptor inhibitors

Chang, Shaohua,Guo, Zhuang,Li, Xue,Sun, Tianwen,Wang, Hai,Wang, Xiaowei,Wang, Yazhou,Xu, Guofeng,Xu, Tianwei,Yu, Wenying,Yu, Zhuangzhuang,Zhang, Yan,Zhao, Liwen

, (2020/05/08)

Inhibition of transforming growth factor β (TGF-β) type 1 receptor (ALK5) provides a feasible approach for the treatment of fibrotic diseases and malignant tumors. In this study, we designed and synthesized a new series of 4-(pyridin-4-oxy)-3-(3,3-difluorocyclobutyl)-pyrazole derivatives, and evaluated biologically as TGF-β type 1 receptor inhibitors. The most potent compound 15r inhibited the ALK5 enzyme and NIH3T3 cell viability with IC50 values of 44 and 42.5 nM, respectively. Compound 15r also displayed better oral plasma exposure and excellent bioavailability than LY-3200882, and in vivo inhibited 65.7% of the tumor growth in a CT26 xenograft mouse model.

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