503424-79-1 Usage
General Description
The chemical compound (3-Methyl-1-benzothien-5-yl)acetonitrile, also known as 3-methylbenzothiophene-5-acetonitrile, is a derivative of benzothiophene with a methyl group at the third position and a cyano group at the fifth position. It is commonly used in the synthesis of pharmaceuticals and agrochemicals due to its versatile reactivity and functionalization potential. (3-Methyl-1-benzothien-5-yl)acetonitrile has been utilized in the development of various drugs and pesticides, as well as in the study of organic reactions and mechanisms. Its unique structure and chemical properties make it a valuable building block for the construction of complex organic molecules in the field of medicinal and agricultural chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 503424-79-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,0,3,4,2 and 4 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 503424-79:
(8*5)+(7*0)+(6*3)+(5*4)+(4*2)+(3*4)+(2*7)+(1*9)=121
121 % 10 = 1
So 503424-79-1 is a valid CAS Registry Number.
503424-79-1Relevant articles and documents
Assembly of α-(Hetero)aryl Nitriles via Copper-Catalyzed Coupling Reactions with (Hetero)aryl Chlorides and Bromides
Chen, Ying,Xu, Lanting,Jiang, Yongwen,Ma, Dawei
, p. 7082 - 7086 (2021)
α-(Hetero)aryl nitriles are important structural motifs for pharmaceutical design. The known methods for direct synthesis of these compounds via coupling with (hetero)aryl halides suffer from narrow reaction scope. Herein, we report that the combination of copper salts and oxalic diamides enables the coupling of a variety of (hetero)aryl halides (Cl, Br) and ethyl cyanoacetate under mild conditions, affording α-(hetero)arylacetonitriles via one-pot decarboxylation. Additionally, the CuBr/oxalic diamide catalyzed coupling of (hetero)aryl bromides with α-alkyl-substituted ethyl cyanoacetates proceeds smoothly at 60 °C, leading to the formation of α-alkyl (hetero)arylacetonitriles after decarboxylation. The method features a general substrate scope and is compatible with various functionalities and heteroaryls.
