50343-26-5

Upstream product

• 108-91-8 cyclohexylamine 
• 1122-17-4 dichloromaleic acid anhydride 

Downstream Products

• 18241-81-1 2-Chlor-N-cyclohexyl-3-(cyclohexylamino)maleinimid 
• 86900-96-1 4-Amino-3-chloro-1-cyclohexyl-5-methoxy-5-phenylethynyl-1,5-dihydro-pyrrol-2-one 
• 344553-54-4 3-Chloro-1-cyclohexyl-2-methoxy-4-oxo-2-phenylethynyl-azetidine-3-carbonitrile 
• 86900-97-2 4-Amino-5-(3-benzyloxy-prop-1-ynyl)-3-chloro-1-cyclohexyl-5-methoxy-1,5-dihydro-pyrrol-2-one 
• 344579-36-8 2-(3-Benzyloxy-prop-1-ynyl)-3-chloro-1-cyclohexyl-2-methoxy-4-oxo-azetidine-3-carbonitrile 
• 86900-98-3 4-Amino-3-chloro-1-cyclohexyl-5-methoxy-5-[5-(tetrahydro-pyran-2-yloxy)-pent-1-ynyl]-1,5-dihydro-pyrrol-2-one 
• 86901-11-3 3-Chloro-1-cyclohexyl-2-methoxy-4-oxo-2-[5-(tetrahydro-pyran-2-yloxy)-pent-1-ynyl]-azetidine-3-carbonitrile 
• 86900-93-8 4-Azido-3-chloro-1-cyclohexyl-5-methoxy-5-phenylethynyl-1,5-dihydro-pyrrol-2-one 
• 86900-94-9 4-Azido-5-(3-benzyloxy-prop-1-ynyl)-3-chloro-1-cyclohexyl-5-methoxy-1,5-dihydro-pyrrol-2-one 
• 86900-95-0 4-Azido-3-chloro-1-cyclohexyl-5-methoxy-5-[5-(tetrahydro-pyran-2-yloxy)-pent-1-ynyl]-1,5-dihydro-pyrrol-2-one 
• 1373308-84-9 2,3-dichloro-N-cyclohexylbicyclo[2.2.2]oct-5-ene-2,3-dicarboximide 

Relevant academic research and scientific papers

Synthesis and optical properties of conjugated maleimide molecules containing amino with aggregation-induced emission enhancement (AIEE)

Maleimide-based luminophores bearing conjugated units are attracting intensive scientific interest as organic luminophores, owing to their excellent light emission properties and wide applications. In this article, after we synthesized amino-maleimide derivatives via a simple route, a series of amino-aryl-maleimide luminophores were synthesized by Suzuki-Miyaura coupling. The obtained luminophores show yellowish-green emission, and the emission maximum wavelength is from 534 nm to 547 nm. In particular, the obtained luminophores have large Stokes shifts (>100 nm) and the emission intensity in the solid state is stronger than that in solution with aggregation-induced emission enhancement (AIEE). In addition, the amino-aryl-maleimide luminophores respond to the increasing polarity of various solvents and show a positive solvatochromic fluorescence.

Anti-leishmanial and cytotoxic activities of a series of maleimides: Synthesis, biological evaluation and structure-activity relationship

In the present study, 45 maleimides have been synthesized and evaluated for anti-leishmanial activities against L. donovani in vitro and cytotoxicity toward THP1 cells. All compounds exhibited obvious anti-leishmanial activities. Among the tested compounds, there were 10 maleimides with superior anti-leishmanial activities to standard drug amphotericin B, and 32 maleimides with superior anti-leishmanial activities to standard drug pentamidine, especially compounds 16 (IC50 50 50 > 10 μg/mL). The anti-leishmanial activities of 16 and 42 were 10 times better than that of amphotericin B. The structure and activity relationship (SAR) studies revealed that 3,4-non-substituted maleimides displayed the strongest anti-leishmanial activities compared to those for 3-methyl-maleimides and 3,4-dichloro-maleimides. 3,4-dichloro-maleimides were the least cytotoxic compared to 3-methyl-maleimides and 3,4-non-substituted maleimides. The results show that several of the reported compounds are promising leads for potential anti-leishmanial drug development.

3,4-Diaminomaleimide Dyes – Simple Luminophores with Efficient Orange-Red Emission in the Solid State

Maleimides have been utilized from materials science to biochemistry. In particular, maleimide-based luminescent dyes have attracted much attention. Recently, we reported arylaminomaleimide dyes that exhibit effective blue-green emission in the solid stat