503446-43-3

Upstream product

• 503446-41-1 (4R,5R,8S,12R)-4,7-Bis-benzyloxy-2-bromo-5-isopropyl-8,12-dimethyl-15-oxo-pentadecanoic acid methyl ester 
• 503446-40-0 (4R,5R,8S,12R)-4,7-Bis-benzyloxy-2-bromo-5-isopropyl-15,15-dimethoxy-8,12-dimethyl-pentadecanoic acid methyl ester 

Downstream Products

• 503446-44-4 (Z)-(5R,9S,10S,12R,13R)-10,13-Bis-benzyloxy-12-isopropyl-5,9-dimethyl-cyclotetradec-2-enecarboxylic acid methyl ester 
• 503546-23-4 (4R,5R,7S,8S,12R)-4,7-Bis-benzyloxy-5-isopropyl-8,12-dimethyl-15-oxa-bicyclo[12.1.0]pentadecane-2-carboxylic acid methyl ester 
• 503446-45-5 (E)-(5R,9S,10S,12R,13R)-10,13-Bis-benzyloxy-3-hydroxy-12-isopropyl-5,9-dimethyl-cyclotetradec-1-enecarboxylic acid methyl ester 

Relevant academic research and scientific papers

Synthetic studies on the dienophile unit of methyl isosartortuoate. Part 2: SmI2-mediated 14-membered carbocyclization

The dienophile unit of methyl isosartortuoate has been synthesized. The 14-membered carbocycle was constructed by a SmI2-mediated intramolecular Reformatsky reaction. The introduction of the oxo group at the γ-position of the α,β-unsaturated ester was achieved by rearrangement of an β,γ-epoxy ester.