50346-47-9Relevant academic research and scientific papers
The synthesis of neurotensin antagonist SR 48692 for prostate cancer research
Baxendale,Cheung,Kitching,Ley,Shearman
, p. 4378 - 4387 (2013/07/27)
An improved synthesis of the molecule SR 48692 is presented and its use as a neurotensin antagonist biological probe for use in cancer research is described. The preparation includes an number of enhanced chemical conversions and strategies to overcome some of the limiting synthetic transformations in the original chemical route.
A flow-based synthesis of 2-aminoadamantane-2-carboxylic acid
Battilocchio, Claudio,Baxendale, Ian R.,Biava, Mariangela,Kitching, Matthew O.,Ley, Steven V.
supporting information; experimental part, p. 798 - 810 (2012/08/27)
The development of a new, high-yielding, scalable and safe process for the preparation of 2-aminoadamantane-2-carboxylic acid (1) is described. This geminal, functionalized achiral amino acid has been reported to possess interesting biological activity as
N-[2-(nitro-1-imidazolyl)ethyl]naphthal imides
-
, (2008/06/13)
Imides having a nitroimidazolylethyl group as a N-substituent are described herein. They are anti-bacterial and anti-protozoal agents. The compounds are prepared by the reaction of the appropriate imide with the chloroethylimidazole or with the tosylate or mesylate of the corresponding hydroxyethyl compound.
