5035-09-6

Usage

Uses

Used in Pharmaceutical Industry:
20α-Acetoxy-4-pregnen-3-one is used as an intermediate in the synthesis of various steroidal drugs for the pharmaceutical industry. Its role in the production of testosterone (T155000) and 4-pregnen-20β-ol-3-one highlights its importance in the development of hormonal treatments and therapies.
Additionally, as an impurity of progesterone (P755900), 20α-Acetoxy-4-pregnen-3-one may be involved in the study and understanding of the side effects or interactions related to the use of progesterone in medical applications. This knowledge can contribute to the improvement of drug safety and efficacy.

Upstream product

• 6147-70-2 20α_F-acetoxy-5β-pregnan-3-one 
• 55547-49-4 acetic acid-(3β-hydroxy-pregnen-(5)-yl-(20α_F)-ester) 
• 78-93-3 butanone 
• 1913-47-9 3β,20α-diacetoxypregn-5-ene 
• 108-24-7 acetic anhydride 

Downstream Products

• 145-14-2 (20S)-20-hydroxypregn-4-en-3-one 

Relevant academic research and scientific papers

17β-aryl(arylmethyl)oxy(thio)alkyl-androstane derivatives

The invention relates to 17β-aryl(arylmethyl)oxy(thio)alkyl-androstane derivatives having general formula (I), wherein R1is (H,OR), (H,OSO3H) or NOR; with R being H, (C1-6)alkyl or (C1-6)acyl; each of R2and R3is independently hydrogen or (C1-6)alyl; n is 0, 1, or 2; X is O, S, S(O) or S(O)2; m is 0 or 1; each of R4, R5and R6is independently hydrogen, hydroxy, (C1-4)alkoxy, halogen, NR7R8or (C1-4)alkyl, optionally substituted by hydroxy, alkoxy, halogen or oxo; each of R7and R8is independently hydrogen or (C1-4)alkyl, and wherein the dotted lines indicate a Δ7or a Δ8double bond, or a pair of conjugated double bonds selected from Δ7,14, Δ8,14and Δ6,8(14); or a pharmaceutically acceptable salt thereof. The compounds of the invention have meiosis regulating activity and can be used for the control of fertility.

17β-allyloxy(thio)alkyl-androstane derivatives for the modulation of meiosis

The invention relates to 17β-allyloxy(thio)alkyl-androstane derivatives having general formula (I) wherein R1is (H, OR), (H, OSO3H) or NOR; with R being H, (C1-6)alkyl or (C1-6)acyl; each of R2and R3is independently hydrogen or (C1-6)alkyl; n is 0, 1 or 2; X is O, S, S(O) or S(O)2; each of R4and R5is independently hydrogen or (C1-4)alkyl; each of R6, R7and R8is independently hydrogen, phenyl, halogen or (C1-4)alkyl, optionally substituted by hydroxy, (C1-4) alkoxy or halogen; or R7and R8together with the carbon atom to which they are bound form a (C3-6)cycloalkane ring; or R6and R7together with the carbon atoms to which they are bound form a (C5-6) cycloalkene ring; and wherein the dotted lines indicate a Δ7or a Δ8double bond, or a pair of conjugated double bonds selected from Δ7,14, Δ8,14and Δ6,8(14); or a pharmaceutically acceptable salt thereof. The compounds of the invention have meiosis activating activity and can be used for the control of fertility.